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ALPP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646551

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ALPP, Polyclonal Antibody
Full Product Name
ALPP, ID (ALPP, PLAP, Alkaline phosphatase, placental type, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1)
Product Gene Name
anti-ALPP antibody
Product Synonym Names
Anti -ALPP, ID (ALPP, PLAP, Alkaline phosphatase, placental type, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
57,954 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (233243348..233247599). Location: 2q37
OMIM
171800
3D Structure
ModBase 3D Structure for P05187
Immunogen
ALPP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the Central region of human ALPP.

Product Categories/Family for anti-ALPP antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-ALPP antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALPP antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-ALPP antibody

Western Blot analysis in Hela cell line lysates (35ug/lane) using MBS646551. This demonstrates that MBS646551 detected the ALPP protein (arrow).
Rabbit Anti-ALPP Polyclonal Antibody – Cat# MBS646551

Immunohistochemistry (IHC) of anti-ALPP antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue using MBS646551 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS646551 for immunohistochemistry.
Rabbit Anti-ALPP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646551

Other Notes

Small volumes of anti-ALPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALPP purchase

MBS646551 is an antibody targeting ALPP. Also known as ALPP, ID (ALPP, PLAP, Alkaline phosphatase, placental type, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALPP. It may not necessarily be applicable to this product.

NCBI GI #
94721246
NCBI GeneID
250
NCBI Accession #
NP_001623.3
UniProt Primary Accession #
P05187
UniProt Secondary Accession #
P05188; P06861; Q53S78; Q96DB7
UniProt Related Accession #
P05187
GenBank Nucleotide #
NM_001632.3
NCBI Official Full Name
alkaline phosphatase, placental type preproprotein
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Official Symbol
ALPP
NCBI Official Synonym Symbols
ALP; PALP; PLAP; PLAP-1
UniProt Protein Name
Alkaline phosphatase, placental type
UniProt Synonym Protein Names
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
Protein Family
Alkaline phosphatase
UniProt Gene Name
ALPP
UniProt Synonym Gene Names
PLAP; PLAP-1
UniProt Entry Name
PPB1_HUMAN
NCBI Protein Information
alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme

UniProt Comments for ALPP

Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor: Binds 1 magnesium ion

By similarity.Binds 2 zinc ions

By similarity.

Subunit structure: Homodimer.

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor Ref.10 Ref.11.

Polymorphism: Placental ALP is highly polymorphic, there are at least three common alleles.

Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

Sequence similarities: Belongs to the alkaline phosphatase family.

Sequence caution: The sequence AAA51708.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on ALPP

1. Calculation of the electrostatic potentials within the active site of human placental alkaline phosphatase also suggests that the local positive electrostatic environment may account for its capability to distinguish various substrates

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALPP antibody

 Reference Product  PubMed Publications
 PTS antibody  >1 publications with ALPP and PTS

Pathways associated with anti-ALPP antibody

 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram

Diseases associated with anti-ALPP antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >146 publications with ALPP and Neoplasms
 Adenocarcinoma Antibodies  >26 publications with ALPP and Adenocarcinoma
 Nervous System Diseases Antibodies  >19 publications with ALPP and Nervous System Diseases
 Lung Diseases Antibodies  >11 publications with ALPP and Lung Diseases
 Breast Neoplasms Antibodies  >6 publications with ALPP and Breast Neoplasms
 Disorders of Sex Development Antibodies  >5 publications with ALPP and Disorders of Sex Development
 Liver Diseases Antibodies  >4 publications with ALPP and Liver Diseases
 Necrosis Antibodies  >3 publications with ALPP and Necrosis
 Mental Disorders Antibodies  >2 publications with ALPP and Mental Disorders
 Pain Antibodies  >2 publications with ALPP and Pain

Organs/Tissues associated with anti-ALPP antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >85 publications with ALPP and Placenta
 Intestine Antibodies  >10 publications with ALPP and Intestine
 Heart Antibodies  >7 publications with ALPP and Heart
 Uterus Antibodies  >6 publications with ALPP and Uterus
 Amniotic Fluid Antibodies  >1 publications with ALPP and Amniotic Fluid
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