Rabbit Anti-AMT Polyclonal Antibody – Cat# MBS8554737

AMT Antibody – Rabbit Polyclonal

Name: AMT Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8554737
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8554737

MBS8554737 is an antibody targeting AMT. Also known as AMT (N-Term) Rabbit pAb. Reactive in Human. Host: Rabbit. More details

$380 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AMT, Polyclonal Antibody

Full Product Name

AMT (N-Term) Rabbit pAb

Product Gene Name

anti-AMT antibody

Product Synonym Names

Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; AMT; GCST

Clonality

Polyclonal

Isotype

Clone Number

RB19704

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Purity/Purification

Affinity Purified

OMIM

238310

3D Structure

ModBase 3D Structure for P48728

Immunogen

This AMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human AMT.

Cellular Localization

Mitochondrion

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-AMT antibody

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Application Notes for anti-AMT antibody

WB: 1:1000
IHC: 1:50-100
FC/FACS: 1:10-50

Other Notes

Small volumes of anti-AMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AMT. It may not necessarily be applicable to this product.

NCBI GI #

44662838

NCBI GeneID

275

NCBI Accession #

NP_000472.2

UniProt Primary Accession #

P48728

UniProt Related Accession #

P48728

GenBank Nucleotide #

NP_000472.2

NCBI Official Full Name

aminomethyltransferase, mitochondrial isoform 1

NCBI Official Synonym Full Names

aminomethyltransferase

NCBI Official Symbol

AMT

NCBI Official Synonym Symbols

GCE; NKH; GCST; GCVT

UniProt Protein Name

Aminomethyltransferase, mitochondrial

UniProt Synonym Protein Names

Glycine cleavage system T protein; GCVT

Protein Family

Probable ammonia channel

UniProt Gene Name

AMT

UniProt Synonym Gene Names

GCST; GCVT

UniProt Entry Name

GCST_HUMAN

NCBI Protein Information

aminomethyltransferase, mitochondrial

NCBI Summary for AMT

This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

UniProt Comments for AMT

AMT: The glycine cleavage system catalyzes the degradation of glycine. Defects in AMT are a cause of non-ketotic hyperglycinemia (NKH); also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. Belongs to the GcvT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.10; Energy Metabolism - nitrogen; Methyltransferase; Mitochondrial

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: aminomethyltransferase activity

Biological Process: glycine catabolic process; glycine decarboxylation via glycine cleavage system; glyoxylate metabolic process

Disease: Glycine Encephalopathy

Research Articles on AMT

1. The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AMT antibody

Reference Product	PubMed Publications
GLDC antibody	>16 publications with AMT and GLDC
GCSH antibody	>14 publications with AMT and GCSH
DLD antibody	>2 publications with AMT and DLD
SHMT2 antibody	>1 publications with AMT and SHMT2

Pathways associated with anti-AMT antibody

Products by Pathway	Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Glycine Degradation Pathway antibodies	Glycine Degradation Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate Metabolism And Glycine Degradation Pathway antibodies	Glyoxylate Metabolism And Glycine Degradation Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram

Diseases associated with anti-AMT antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>312 publications with AMT and Nervous System Diseases
Brain Diseases Antibodies	>132 publications with AMT and Brain Diseases
Cardiovascular Diseases Antibodies	>105 publications with AMT and Cardiovascular Diseases
Inflammation Antibodies	>101 publications with AMT and Inflammation
Vascular Diseases Antibodies	>84 publications with AMT and Vascular Diseases
Heart Diseases Antibodies	>55 publications with AMT and Heart Diseases
Depressive Disorder Antibodies	>50 publications with AMT and Depressive Disorder
Memory Disorders Antibodies	>49 publications with AMT and Memory Disorders
Disease Models, Animal Antibodies	>44 publications with AMT and Disease Models, Animal
Cognition Disorders Antibodies	>38 publications with AMT and Cognition Disorders

Organs/Tissues associated with anti-AMT antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>369 publications with AMT and Blood
Brain Antibodies	>300 publications with AMT and Brain
Eye Antibodies	>198 publications with AMT and Eye
Embryonic Tissue Antibodies	>185 publications with AMT and Embryonic Tissue
Muscle Antibodies	>134 publications with AMT and Muscle
Vascular Antibodies	>80 publications with AMT and Vascular
Bone Antibodies	>79 publications with AMT and Bone
Liver Antibodies	>73 publications with AMT and Liver
Heart Antibodies	>65 publications with AMT and Heart
Kidney Antibodies	>49 publications with AMT and Kidney