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ANO7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6273825

ANO7 may act as a calcium-activated chloride channel. This protein May play a role in cell-cell interactions. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ANO7, Polyclonal Antibody
Full Product Name
ANO7, NT (ANO7, NGEP, PCANAP5, TMEM16G, Anoctamin-7, Dresden transmembrane protein of the prostate, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G) (MaxLight 550)
Product Gene Name
anti-ANO7 antibody
Product Synonym Names
ANO7; NGEP; PCANAP5; TMEM16G; Anoctamin-7; Dresden transmembrane protein of the prostate; IPCA-5; New gene expressed in prostate; Prostate cancer-associated protein 5; Transmembrane protein 16G
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human ANO7.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
105,532 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (242127924..242164791). Location: 2q37.3
OMIM
605096
3D Structure
ModBase 3D Structure for Q6IWH7
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 106-135 in the N-terminal region of human ANO7, UniProt Accession #Q6IWH7.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-ANO7 antibody

Antibodies; Transmembrane Proteins
Applications Tested/Suitable for anti-ANO7 antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-ANO7 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ANO7 antibody

Western Blot analysis in MCF-7 cell line lysates (35ug/lane) usingMBS6005848. ANO7 (arrow) was detected using the purified Pab.
Rabbit Anti-ANO7 Polyclonal Antibody – Cat# MBS6273825

Flow Cytometry (FC/FACS) of anti-ANO7 antibody

Flow Cytometry analysis of MCF-7 cells using MBS6005848 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ANO7 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6273825

Product References and Citations for anti-ANO7 antibody

1. Cereda, V., et al. Cancer Immunol. Immunother. 59(1):63-71(2010). 2. Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009). 3. Das, S., et al. Cancer Res. 68(15):6306-6312(2008). 4. Kiessling, A., et al. Prostate 64(4):387-400(2005). 5. Katoh, M., et al. Int. J. Mol. Med. 14(4):759-764(2004).

Other Notes

Small volumes of anti-ANO7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANO7 purchase

MBS6273825 is an antibody targeting ANO7. Also known as ANO7, NT (ANO7, NGEP, PCANAP5, TMEM16G, Anoctamin-7, Dresden transmembrane protein of the prostate, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANO7. It may not necessarily be applicable to this product.

NCBI GI #
48717269
NCBI GeneID
50636
NCBI Accession #
NP_001001666.1
UniProt Primary Accession #
Q6IWH7
UniProt Secondary Accession #
Q6IWH6
UniProt Related Accession #
Q6IWH7
GenBank Nucleotide #
NM_001001666.3
NCBI Official Full Name
anoctamin-7 isoform NGEP-short
NCBI Official Synonym Full Names
anoctamin 7
NCBI Official Symbol
ANO7
NCBI Official Synonym Symbols
NGEP; DTMPP; IPCA5; D-TMPP; IPCA-5; PCANAP5; TMEM16G; PCANAP5L
UniProt Protein Name
Anoctamin-7
UniProt Synonym Protein Names
Dresden transmembrane protein of the prostate; D-TMPP; IPCA-5; New gene expressed in prostate; Prostate cancer-associated protein 5; Transmembrane protein 16G
Protein Family
Anoctamin
UniProt Gene Name
ANO7
UniProt Synonym Gene Names
NGEP; PCANAP5; TMEM16G; D-TMPP
UniProt Entry Name
ANO7_HUMAN
NCBI Protein Information
anoctamin-7; transmembrane protein 16G; prostate cancer associated protein 5; Dresden-transmembrane protein of the prostate

NCBI Summary for ANO7

This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

UniProt Comments for ANO7

ANO7: May act as a calcium-activated chloride channel. May play a role in cell-cell interactions. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Channel, chloride; Calcium-binding; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: endoplasmic reticulum; integral to membrane; plasma membrane; intracellular; nucleus; cytosol; cell junction

Molecular Function: phospholipid scramblase activity; intracellular calcium activated chloride channel activity

Biological Process: chloride transport; lipid transport; transmembrane transport
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Research Articles on ANO7

1. NGEP is a potential target for T cell-mediated immunotherapy of prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ANO7 antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ANO7 antibody

 Disease Name  Pubmed Publications
 Genital Diseases, Male Antibodies  >6 publications with ANO7 and Genital Diseases, Male
 Neoplasms Antibodies  >6 publications with ANO7 and Neoplasms
 Hyperplasia Antibodies  >2 publications with ANO7 and Hyperplasia

Organs/Tissues associated with anti-ANO7 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >8 publications with ANO7 and Prostate
 Blood Antibodies  >1 publications with ANO7 and Blood
 Eye Antibodies  >1 publications with ANO7 and Eye
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