ARL2 Antibody – Rabbit Polyclonal

ARL2: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Belongs to the small GTPase superfamily. Arf family.

Protein type: Mitochondrial; G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: centrosome; mitochondrial intermembrane space; nucleus; lateral plasma membrane

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GTPase inhibitor activity

Biological Process: tubulin folding; metabolic process; centrosome organization and biogenesis; positive regulation of microtubule polymerization; small GTPase mediated signal transduction; maintenance of protein localization in nucleus; cell cycle; regulation of microtubule polymerization