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BIM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2554618

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Bim, Polyclonal Antibody
Full Product Name
Bim Polyclonal Antibody
Product Gene Name
anti-Bim antibody
Product Synonym Names
BCL2 like 11; B2L11; BAM; Bcl 2 interacting protein Bim; Bcl 2 related ovarian death agonist; Bcl-2-like protein 11; BCL2 interacting mediator of cell death; BCL2 like 11 (apoptosis facilitator); BCL2 like protein 11; Bcl2-interacting mediator of cell death; Bcl2-L-11; Bcl2l11; BIM alpha6; BIM; BIM beta6; BIM beta7; BimEL; BimL; BOD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity/Purification
Affinity Purification
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
4-22kDa
3D Structure
ModBase 3D Structure for O43521
Immunogen
Recombinant protein of human BCL2L11
Conjugation
Unconjugated

Product Categories/Family for anti-Bim antibody

Cancer; Cell Biology; Metabolism; Immunology; Neuroscience; Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-Bim antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-Bim antibody
IHC: 1:50-1:100
IF: 1:50-1:100

Immunohistochemistry (IHC) of anti-Bim antibody

Immunohistochemistry of paraffin-embedded human tonsil using BCL2L11 antibody.
Rabbit Anti-BIM Polyclonal Antibody – Cat# MBS2554618

Immunohistochemistry (IHC) of anti-Bim antibody

Immunohistochemistry of paraffin-embedded human liver using BCL2L11 antibody.
Rabbit Anti-BIM Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2554618

Immunofluorescence (IF) of anti-Bim antibody

Immunofluorescence analysis of HeLa cells using BCL2L11 antibody.
Rabbit Anti-BIM Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2554618

Other Notes

Small volumes of anti-Bim antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bim purchase

MBS2554618 is an antibody targeting Bim. Also known as Bim Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Bim. It may not necessarily be applicable to this product.

NCBI GI #
323362959
NCBI GeneID
10018
NCBI Accession #
NP_001191035.1
UniProt Primary Accession #
O43521
UniProt Secondary Accession #
O43522; Q0MSE7; Q0MSE8; Q0MSE9; Q53R28; Q6JTU6; Q6T851; Q6TE14; Q6TE15; Q6TE16; A8K2W2
UniProt Related Accession #
O43521
GenBank Nucleotide #
NM_001204106.1
NCBI Official Full Name
bcl-2-like protein 11 isoform 11
NCBI Official Synonym Full Names
BCL2 like 11
NCBI Official Symbol
BCL2L11
NCBI Official Synonym Symbols
BAM; BIM; BOD
UniProt Protein Name
Bcl-2-like protein 11
UniProt Synonym Protein Names
Bcl2-interacting mediator of cell death
UniProt Gene Name
BCL2L11
UniProt Synonym Gene Names
BIM; Bcl2-L-11
NCBI Protein Information
bcl-2-like protein 11

UniProt Comments for Bim

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
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Research Articles on Bim

1. POH1 knockdown induced cell apoptosis through increased expression of p53 and Bim.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Bim antibody

 Reference Product  PubMed Publications
 BCL2 antibody  >8 publications with Bim and BCL2
 BCL2L1 antibody  >5 publications with Bim and BCL2L1
 MAPK8 antibody  >3 publications with Bim and MAPK8
 FOXO3 antibody  >3 publications with Bim and FOXO3
 DYNLL1 antibody  >1 publications with Bim and DYNLL1

Pathways associated with anti-Bim antibody

 Products by Pathway  Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of BIM And Translocation To Mitochondria Pathway antibodies  Activation Of BIM And Translocation To Mitochondria Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies  BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram

Diseases associated with anti-Bim antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >35 publications with Bim and Neoplasms
 Adenocarcinoma Antibodies  >8 publications with Bim and Adenocarcinoma
 Nervous System Diseases Antibodies  >4 publications with Bim and Nervous System Diseases
 Necrosis Antibodies  >4 publications with Bim and Necrosis
 Drug Toxicity Antibodies  >3 publications with Bim and Drug Toxicity
 Brain Diseases Antibodies  >3 publications with Bim and Brain Diseases
 Neoplasm Metastasis Antibodies  >3 publications with Bim and Neoplasm Metastasis
 Liver Diseases Antibodies  >2 publications with Bim and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with Bim and Kidney Diseases
 Inflammation Antibodies  >2 publications with Bim and Inflammation

Organs/Tissues associated with anti-Bim antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with Bim and Blood
 Brain Antibodies  >4 publications with Bim and Brain
 Thymus Antibodies  >2 publications with Bim and Thymus
 Muscle Antibodies  >2 publications with Bim and Muscle
 Embryonic Tissue Antibodies  >1 publications with Bim and Embryonic Tissue
 Testis Antibodies  >1 publications with Bim and Testis
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