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BNIP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6278712

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BNIP2, Polyclonal Antibody
Full Product Name
BNIP2, CT (BNIP2, NIP2, BCL2/adenovirus E1B 19kD protein-interacting protein 2) (MaxLight 750)
Product Gene Name
anti-BNIP2 antibody
Product Synonym Names
BNIP2; NIP2; BCL2/adenovirus E1B 19kD protein-interacting protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
36,018 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (59955061..59981642, complement). Location: 15q22.2
OMIM
603292
3D Structure
ModBase 3D Structure for Q12982
Immunogen
BNIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-435 amino acids from the C-terminal region of human BNIP2.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-BNIP2 antibody

Antibodies; Infectious Disease Adenovirus
Applications Tested/Suitable for anti-BNIP2 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-BNIP2 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-BNIP2 antibody

Scott, G.B., et al. Biochem. J. 431(3):423-431(2010). Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). Valencia, C.A., et al. Biochem. Biophys. Res. Commun. 364(3):495-501(2007). Zhou, Y.T., et al. Exp. Cell Res. 303(2):263-274(2005). Shang, X., et al. J. Biol. Chem. 278(46):45903-45914(2003).

Other Notes

Small volumes of anti-BNIP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BNIP2 purchase

MBS6278712 is an antibody targeting BNIP2. Also known as BNIP2, CT (BNIP2, NIP2, BCL2/adenovirus E1B 19kD protein-interacting protein 2) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BNIP2. It may not necessarily be applicable to this product.

NCBI GI #
168480080
NCBI GeneID
663
NCBI Accession #
NP_004321.2
UniProt Primary Accession #
Q12982
UniProt Secondary Accession #
B4DS94
UniProt Related Accession #
Q12982
GenBank Nucleotide #
NM_004330.2
NCBI Official Full Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
NCBI Official Synonym Full Names
BCL2/adenovirus E1B 19kDa interacting protein 2
NCBI Official Symbol
BNIP2
NCBI Official Synonym Symbols
NIP2; BNIP-2
UniProt Protein Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Protein Family
BCL2/adenovirus E1B 19 kDa protein-interacting protein
UniProt Gene Name
BNIP2
UniProt Synonym Gene Names
NIP2
UniProt Entry Name
BNIP2_HUMAN
NCBI Protein Information
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

NCBI Summary for BNIP2

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. [provided by RefSeq, Mar 2011]
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UniProt Comments for BNIP2

BNIP2: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; cytosol

Molecular Function: identical protein binding; protein binding; calcium ion binding; GTPase activator activity

Biological Process: muscle cell differentiation; apoptosis; positive regulation of muscle cell differentiation; positive regulation of GTPase activity; negative regulation of apoptosis
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Research Articles on BNIP2

1. Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BNIP2 antibody

 Reference Product  PubMed Publications
 CDC42 antibody  >8 publications with BNIP2 and CDC42
 BCL2 antibody  >4 publications with BNIP2 and BCL2
 FGFR1 antibody  >1 publications with BNIP2 and FGFR1
 BNIPL antibody  >1 publications with BNIP2 and BNIPL
 ARHGAP8 antibody  >1 publications with BNIP2 and ARHGAP8

Pathways associated with anti-BNIP2 antibody

 Products by Pathway  Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram

Diseases associated with anti-BNIP2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with BNIP2 and Neoplasms
 Necrosis Antibodies  >2 publications with BNIP2 and Necrosis
 Brain Diseases Antibodies  >1 publications with BNIP2 and Brain Diseases
 Immune System Diseases Antibodies  >1 publications with BNIP2 and Immune System Diseases
 Disease Models, Animal Antibodies  >1 publications with BNIP2 and Disease Models, Animal
 Drug Toxicity Antibodies  >1 publications with BNIP2 and Drug Toxicity
 Inflammation Antibodies  >1 publications with BNIP2 and Inflammation

Organs/Tissues associated with anti-BNIP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with BNIP2 and Brain
 Nerve Antibodies  >3 publications with BNIP2 and Nerve
 Blood Antibodies  >3 publications with BNIP2 and Blood
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