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CCT5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7112828

MBS7112828 is an antibody targeting CCT5. Also known as CCT5 Antibody. Reactive in Human. Host: Rabbit. More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCT5, Polyclonal Antibody
Full Product Name
CCT5 Antibody
Product Gene Name
anti-CCT5 antibody
Product Synonym Names
T-complex protein 1 subunit epsilon; TCP-1-epsilon; CCT-epsilon; CCT5; CCTE; KIAA0098
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%
Protein G Purified
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: CCT5 (MBS7112828)
HRP Conjugated Antibody: CCT5 (MBS7112829)
Matching Pairs
Unconjugated Antibody: CCT5 (MBS7112828)
FITC Conjugated Antibody: CCT5 (MBS7112830)
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Molecular Weight
49,526 Da
3D Structure
ModBase 3D Structure for P48643
Immunogen Species
Human
Immunogen
Recombinant Human T-complex protein 1 subunit epsilon protein (1-270AA)
Conjugate
Non-Conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4

Product Categories/Family for anti-CCT5 antibody

Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CCT5 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-CCT5 antibody
WB: 1:500-1:5000
IF: 1:50-1:200

Western Blot (WB) of anti-CCT5 antibody

Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HepG2 whole cell lysate
All lanes: CCT5 antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60, 50 kDa
Observed band size: 60 kDa
Rabbit Anti-CCT5 Polyclonal Antibody – Cat# MBS7112828

Immunofluorescence (IF) of anti-CCT5 antibody

Immunofluorescence staining of A549 cells with CSB-PA004862EA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Rabbit Anti-CCT5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS7112828

Other Notes

Small volumes of anti-CCT5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCT5. It may not necessarily be applicable to this product.

NCBI GI #
807066364
NCBI GeneID
22948
NCBI Accession #
NP_001293084.1
UniProt Primary Accession #
P48643
UniProt Secondary Accession #
A8JZY8; A8K2X8; B4DYD8
UniProt Related Accession #
P48643
GenBank Nucleotide #
NM_001306155.1
NCBI Official Full Name
T-complex protein 1 subunit epsilon isoform d
NCBI Official Synonym Full Names
chaperonin containing TCP1 subunit 5
NCBI Official Symbol
CCT5
NCBI Official Synonym Symbols
CCTE; HEL-S-69; PNAS-102; CCT-epsilon; TCP-1-epsilon
UniProt Protein Name
T-complex protein 1 subunit epsilon
UniProt Synonym Protein Names
CCT-epsilon
Protein Family
T-complex protein
UniProt Gene Name
CCT5
UniProt Synonym Gene Names
; TCP-1-epsilon
NCBI Protein Information
T-complex protein 1 subunit epsilon

NCBI Summary for CCT5

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
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UniProt Comments for CCT5

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
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Research Articles on CCT5

1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCT5 antibody

 Reference Product  PubMed Publications
 CCT4 antibody  >7 publications with CCT5 and CCT4
 TCP1 antibody  >6 publications with CCT5 and TCP1
 CCT2 antibody  >3 publications with CCT5 and CCT2
 CCT7 antibody  >2 publications with CCT5 and CCT7
 CCT8 antibody  >2 publications with CCT5 and CCT8
 CCT3 antibody  >1 publications with CCT5 and CCT3

Pathways associated with anti-CCT5 antibody

 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 BBSome-mediated Cargo-targeting To Cilium Pathway antibodies  BBSome-mediated Cargo-targeting To Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Cooperation Of PDCL (PhLP1) And TRiC/CCT In G-protein Beta Folding Pathway antibodies  Cooperation Of PDCL (PhLP1) And TRiC/CCT In G-protein Beta Folding Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Folding Of Actin By CCT/TriC Pathway antibodies  Folding Of Actin By CCT/TriC Pathway Diagram
 Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies  Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram

Diseases associated with anti-CCT5 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >2 publications with CCT5 and Neoplasm Metastasis
 Nerve Degeneration Antibodies  >2 publications with CCT5 and Nerve Degeneration
 Neoplasms, Experimental Antibodies  >2 publications with CCT5 and Neoplasms, Experimental
 Cognition Disorders Antibodies  >2 publications with CCT5 and Cognition Disorders
 Inflammation Antibodies  >2 publications with CCT5 and Inflammation
 Breast Neoplasms Antibodies  >2 publications with CCT5 and Breast Neoplasms
 Testicular Diseases Antibodies  >1 publications with CCT5 and Testicular Diseases
 Atrophy Antibodies  >1 publications with CCT5 and Atrophy
 Infertility, Male Antibodies  >1 publications with CCT5 and Infertility, Male
 Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive Antibodies  >1 publications with CCT5 and Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive

Organs/Tissues associated with anti-CCT5 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >4 publications with CCT5 and Nerve
 Brain Antibodies  >3 publications with CCT5 and Brain
 Muscle Antibodies  >2 publications with CCT5 and Muscle
 Testis Antibodies  >2 publications with CCT5 and Testis
 Lymph Antibodies  >1 publications with CCT5 and Lymph
 Vascular Antibodies  >1 publications with CCT5 and Vascular
 Stomach Antibodies  >1 publications with CCT5 and Stomach
 Pancreas Antibodies  >1 publications with CCT5 and Pancreas
 Blood Antibodies  >1 publications with CCT5 and Blood
 Intestine Antibodies  >1 publications with CCT5 and Intestine
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