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CD271 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6282984

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD271, Polyclonal Antibody
Full Product Name
CD271, CT (NGFR, TNFRSF16, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, p75 ICD, CD271) (Biotin)
Product Gene Name
anti-CD271 antibody
Product Synonym Gene Name
NGFR
Product Synonym Names
NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; p75 ICD; CD271
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,183 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (47572655..47592382). Location: 17q21-q22
OMIM
162010
3D Structure
ModBase 3D Structure for P08138
Immunogen
CD271 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-381 amino acids from the C-terminal region of human CD271.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-CD271 antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-CD271 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CD271 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CD271 antibody

CD271 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CD271 antibody detected the CD271 protein (arrow).
Rabbit Anti-CD271 Polyclonal Antibody – Cat# MBS6282984

Immunohistochemistry (IHC) of anti-CD271 antibody

CD271 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CD271 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CD271 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6282984

Product References and Citations for anti-CD271 antibody

Boiko, A.D., et al. Nature 466(7302):133-137(2010). Ceni, C., et al. J. Cell. Sci. 123 (PT 13), 2299-2307 (2010): Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010). Bosker, F.J., et al. Mol. Psychiatry (2010). In press: Sornelli, F., et al. Mol. Vis. 16, 1439-1447 (2010).

Other Notes

Small volumes of anti-CD271 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD271 purchase

MBS6282984 is an antibody targeting CD271. Also known as CD271, CT (NGFR, TNFRSF16, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, p75 ICD, CD271) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD271. It may not necessarily be applicable to this product.

NCBI GI #
4505393
NCBI GeneID
4804
NCBI Accession #
NP_002498.1
UniProt Primary Accession #
P08138
UniProt Secondary Accession #
B2R961
UniProt Related Accession #
P08138
GenBank Nucleotide #
NM_002507.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 16
NCBI Official Synonym Full Names
nerve growth factor receptor
NCBI Official Symbol
NGFR
NCBI Official Synonym Symbols
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 16
UniProt Synonym Protein Names
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD
UniProt Gene Name
NGFR
UniProt Synonym Gene Names
TNFRSF16; NGF receptor
UniProt Entry Name
TNR16_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor

UniProt Comments for CD271

NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; extracellular region; plasma membrane; cytosol; endosome

Molecular Function: signal transducer activity; protein binding; transmembrane receptor activity; ubiquitin protein ligase binding; death receptor activity; nerve growth factor binding; receptor activity; Rab GTPase binding

Biological Process: detection of temperature stimulus; axon guidance; hair follicle morphogenesis; membrane protein intracellular domain proteolysis; central nervous system development; nerve growth factor receptor signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of odontogenesis of dentine-containing teeth; regulation of caspase activity; glucose homeostasis; regulation of axonogenesis; negative regulation of hair follicle development; negative regulation of cell cycle; intracellular protein transport; positive regulation of fibroblast proliferation; negative regulation of axonogenesis; positive regulation of axonogenesis; nerve development; circadian regulation of gene expression; negative regulation of apoptosis
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Research Articles on CD271

1. the juxtamembrane region of p75(ICD) acts to cause a conformational change within the extracellular domain of TrkA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD271 antibody

 Reference Product  PubMed Publications
 NGF antibody  >232 publications with CD271 and NGF
 NTRK1 antibody  >101 publications with CD271 and NTRK1
 NTRK2 antibody  >30 publications with CD271 and NTRK2
 NTRK3 antibody  >17 publications with CD271 and NTRK3
 MAG antibody  >3 publications with CD271 and MAG
 NTF4 antibody  >3 publications with CD271 and NTF4
 MAPK1 antibody  >2 publications with CD271 and MAPK1
 GRB2 antibody  >2 publications with CD271 and GRB2
 RTN4R antibody  >2 publications with CD271 and RTN4R
 SHC1 antibody  >2 publications with CD271 and SHC1

Pathways associated with anti-CD271 antibody

 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Ceramide Signalling Pathway antibodies  Ceramide Signalling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
 NF-kB Is Activated And Signals Survival Pathway antibodies  NF-kB Is Activated And Signals Survival Pathway Diagram
 NFG And ProNGF Binds To P75NTR Pathway antibodies  NFG And ProNGF Binds To P75NTR Pathway Diagram

Diseases associated with anti-CD271 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >158 publications with CD271 and Neoplasms
 Nervous System Diseases Antibodies  >116 publications with CD271 and Nervous System Diseases
 Brain Diseases Antibodies  >56 publications with CD271 and Brain Diseases
 Necrosis Antibodies  >40 publications with CD271 and Necrosis
 Neurodegenerative Diseases Antibodies  >34 publications with CD271 and Neurodegenerative Diseases
 Nerve Degeneration Antibodies  >31 publications with CD271 and Nerve Degeneration
 Inflammation Antibodies  >23 publications with CD271 and Inflammation
 Disease Models, Animal Antibodies  >23 publications with CD271 and Disease Models, Animal
 Mental Disorders Antibodies  >20 publications with CD271 and Mental Disorders
 Kidney Diseases Antibodies  >14 publications with CD271 and Kidney Diseases

Organs/Tissues associated with anti-CD271 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >184 publications with CD271 and Brain
 Mixed Antibodies  >9 publications with CD271 and Mixed
 Spleen Antibodies  >3 publications with CD271 and Spleen
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