• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CD58 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9703640

CD58 encodes a member of the immunoglobulin superfamily. The CD58 molecule is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
CD58, Polyclonal Antibody
Full Product Name
CD58 Polyclonal Antibody
Product Gene Name
anti-CD58 antibody
Product Synonym Names
Rabbit Anti-CD58 Polyclonal Antibody; CD58; LFA3; Lymphocyte function-associated antigen 3; Ag3; Surface glycoprotein LFA-3; CD58
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid; PBS Containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml (lot specific)
Specificity
CD58 Polyclonal Antibody detects endogenous levels of CD58 protein.
Preparation and Storage
Stable for one year at -20 degree C from date of shipment.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
OMIM
153420
3D Structure
ModBase 3D Structure for P19256
Immunogen
Synthesized peptide derived from the internal region of human CD58
Applications Tested/Suitable for anti-CD58 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes for anti-CD58 antibody
WB: 1:500-1:2000
IHC-P: 1:100-1:300
ELISA: 1:20000

Western Blot (WB) of anti-CD58 antibody

Fig.1. Western Blot analysis of K562 cells using CD58 Polyclonal Antibody. Secondary antibody was diluted at 1:20000.
Rabbit Anti-CD58 Polyclonal Antibody – Cat# MBS9703640

Immunohistochemistry (IHC) of anti-CD58 antibody

Fig.2. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100.
Rabbit Anti-CD58 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9703640

Immunohistochemistry (IHC) of anti-CD58 antibody

Fig.3. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100.
Rabbit Anti-CD58 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9703640

Immunohistochemistry (IHC) of anti-CD58 antibody

Fig.4. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100.
Rabbit Anti-CD58 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9703640

Immunohistochemistry (IHC) of anti-CD58 antibody

Fig.5. Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:100.
Rabbit Anti-CD58 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9703640

Immunohistochemistry (IHC) of anti-CD58 antibody

Fig.6. Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:100.
Rabbit Anti-CD58 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9703640

Other Notes

Small volumes of anti-CD58 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD58 purchase

MBS9703640 is an antibody targeting CD58. Also known as CD58 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD58. It may not necessarily be applicable to this product.

NCBI GI #
221316575
NCBI GeneID
965
NCBI Accession #
NP_001138294.1
UniProt Primary Accession #
P19256
UniProt Related Accession #
P19256
GenBank Nucleotide #
NP_001138294.1
NCBI Official Full Name
lymphocyte function-associated antigen 3 isoform 2
NCBI Official Synonym Full Names
CD58 molecule
NCBI Official Symbol
CD58
NCBI Official Synonym Symbols
ag3; LFA3; LFA-3
UniProt Protein Name
Lymphocyte function-associated antigen 3
UniProt Synonym Protein Names
Surface glycoprotein LFA-3
Protein Family
Lymphocyte function-associated antigen
UniProt Gene Name
CD58
UniProt Synonym Gene Names
LFA3; Ag3
UniProt Entry Name
LFA3_HUMAN
NCBI Protein Information
lymphocyte function-associated antigen 3

NCBI Summary for CD58

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Show more

UniProt Comments for CD58

CD58: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell adhesion; blood coagulation; leukocyte migration
Show more

Research Articles on CD58

1. Across different global populations and data sets, carriers of the multiple sclerosis risk allele showed reduced CD58 mRNA levels but increased hsa-miR-548ac levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD58 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000