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CNOT6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6287298

The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNOT6, Polyclonal Antibody
Full Product Name
CNOT6, CT (CNOT6, CCR4, KIAA1194, CCR4-NOT transcription complex subunit 6, CCR4 carbon catabolite repression 4-like, Carbon catabolite repressor protein 4 homolog, Cytoplasmic deadenylase) (FITC)
Product Gene Name
anti-CNOT6 antibody
Product Synonym Names
CNOT6; CCR4; KIAA1194; CCR4-NOT transcription complex subunit 6; CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
63,307 Da
OMIM
608951
3D Structure
ModBase 3D Structure for Q9ULM6
Immunogen
CNOT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 415-442 amino acids selected from the C-terminal region of human CNOT6.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CNOT6 antibody

Antibodies; DEAD Box Proteins
Applications Tested/Suitable for anti-CNOT6 antibody
Western Blot (WB), FLISA
Application Notes for anti-CNOT6 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CNOT6 antibody

CNOT6 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CNOT6 antibody detected the CNOT6 protein (arrow).
Rabbit Anti-CNOT6 Polyclonal Antibody – Cat# MBS6287298

Product References and Citations for anti-CNOT6 antibody

Edwards, T.L., et al. Ann. Hum. Genet. 74(2):97-109(2010). Lau, N.C., et al. Biochem. J. 422(3):443-453(2009). Sanchez-Perez, I., et al. Cancer Lett. 273(2):281-291(2009). Garapaty, S., et al. J. Biol. Chem. 283(11):6806-6816(2008). Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007).

Other Notes

Small volumes of anti-CNOT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNOT6 purchase

MBS6287298 is an antibody targeting CNOT6. Also known as CNOT6, CT (CNOT6, CCR4, KIAA1194, CCR4-NOT transcription complex subunit 6, CCR4 carbon catabolite repression 4-like, Carbon catabolite repressor protein 4 homolog, Cytoplasmic deadenylase) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CNOT6. It may not necessarily be applicable to this product.

NCBI GI #
53829366
NCBI GeneID
57472
NCBI Accession #
NP_056270.2
UniProt Primary Accession #
Q9ULM6
UniProt Secondary Accession #
A7MD46; D3DWR0
UniProt Related Accession #
Q9ULM6
GenBank Nucleotide #
NM_015455
NCBI Official Synonym Full Names
CCR4-NOT transcription complex subunit 6
NCBI Official Symbol
CNOT6
NCBI Official Synonym Symbols
CCR4; Ccr4a
UniProt Protein Name
CCR4-NOT transcription complex subunit 6
UniProt Synonym Protein Names
CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase
Protein Family
CCR4-NOT transcription complex
UniProt Gene Name
CNOT6
UniProt Synonym Gene Names
CCR4; CCR4a; KIAA1194
UniProt Entry Name
CNOT6_HUMAN
NCBI Protein Information
CCR4-NOT transcription complex subunit 6

NCBI Summary for CNOT6

This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
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Research Articles on CNOT6

1. Studied hepatic role in metabolic homeostasis of fibroblast growth factor 21(FGF21) and the "CCR4-NOT complex" (a multisubunit protein complex composed of "CCR4-NOT transcription complex subunit 6 like" (CNOT6L) and "CCR4-NOT transcription complex subunit 6" (CNOT6). Results show CNOT6L plays a major role in regulation FGF21 levels.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNOT6 antibody

 Reference Product  PubMed Publications
 CNOT7 antibody  >6 publications with CNOT6 and CNOT7
 CNOT1 antibody  >5 publications with CNOT6 and CNOT1
 CNOT8 antibody  >5 publications with CNOT6 and CNOT8
 CNOT3 antibody  >2 publications with CNOT6 and CNOT3
 CNOT2 antibody  >2 publications with CNOT6 and CNOT2
 RQCD1 antibody  >1 publications with CNOT6 and RQCD1

Pathways associated with anti-CNOT6 antibody

 Products by Pathway  Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with anti-CNOT6 antibody

 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >1 publications with CNOT6 and Abnormalities, Multiple
 Abnormalities, Drug-Induced Antibodies  >1 publications with CNOT6 and Abnormalities, Drug-Induced

Organs/Tissues associated with anti-CNOT6 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with CNOT6 and Bone
 Eye Antibodies  >1 publications with CNOT6 and Eye
 Brain Antibodies  >1 publications with CNOT6 and Brain
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