CNTN2 Antibody – Rabbit Polyclonal

This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016]

CNTN2: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. Belongs to the immunoglobulin superfamily. Contactin family.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: voltage-gated potassium channel complex; cell surface; cell soma; integral to plasma membrane; plasma membrane; synapse; myelin sheath

Molecular Function: identical protein binding; protein self-association; carbohydrate binding; glycoprotein binding

Biological Process: axon guidance; cerebral cortex GABAergic interneuron migration; myelination in the central nervous system; positive regulation of adenosine receptor signaling pathway; axonal fasciculation; regulation of astrocyte differentiation; microtubule cytoskeleton organization and biogenesis; learning; adult walking behavior; negative regulation of neuron differentiation; receptor internalization; clustering of voltage-gated potassium channels; regulation of axon diameter; cell adhesion; regulation of neuronal synaptic plasticity

Disease: Epilepsy, Familial Adult Myoclonic, 5