Rabbit Anti-CYC1 Polyclonal Antibody – Cat# MBS6290362

CYC1 Antibody – Rabbit Polyclonal

Name: CYC1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6290362
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6290362

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CYC1, Polyclonal Antibody

Full Product Name

CYC1, CT (CYC1, Cytochrome c1, heme protein, mitochondrial, Complex III subunit 4, Complex III subunit IV, Cytochrome b-c1 complex subunit 4, Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (MaxLight 750)

Product Gene Name

anti-CYC1 antibody

Product Synonym Names

CYC1; Cytochrome c1; heme protein, mitochondrial; Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

35,422 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (145149960..145152428). Location: 8q24.3

OMIM

123980

3D Structure

ModBase 3D Structure for P08574

Immunogen

CYC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-297 amino acids from the C-terminal region of human CYC1.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-CYC1 antibody

Antibodies; Enzymes; Cytochrome

Applications Tested/Suitable for anti-CYC1 antibody

Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)

Application Notes for anti-CYC1 antibody

FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-CYC1 antibody

Cummings, C., et al. Apoptosis 11(7):1121-1129(2006). Wen, J.J., et al. Free Radic. Biol. Med. 37(12):2072-2081(2004). An, J., et al. J. Biol. Chem. 279(18):19133-19140(2004).

Other Notes

Small volumes of anti-CYC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYC1 purchase

MBS6290362 is an antibody targeting CYC1. Also known as CYC1, CT (CYC1, Cytochrome c1, heme protein, mitochondrial, Complex III subunit 4, Complex III subunit IV, Cytochrome b-c1 complex subunit 4, Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYC1. It may not necessarily be applicable to this product.

NCBI GI #

21359867

NCBI GeneID

1537

NCBI Accession #

NP_001907.2

UniProt Primary Accession #

P08574

UniProt Secondary Accession #

Q5U062; Q6FHS7

UniProt Related Accession #

P08574

GenBank Nucleotide #

NM_001916.3

NCBI Official Full Name

cytochrome c1, heme protein, mitochondrial

NCBI Official Synonym Full Names

cytochrome c-1

NCBI Official Symbol

CYC1

NCBI Official Synonym Symbols

UQCR4

UniProt Protein Name

Cytochrome c1, heme protein, mitochondrial

UniProt Synonym Protein Names

Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit

Protein Family

Cytochrome

UniProt Gene Name

CYC1

UniProt Synonym Gene Names

Cytochrome c-1

UniProt Entry Name

CY1_HUMAN

NCBI Protein Information

cytochrome c1, heme protein, mitochondrial; complex III subunit 4; complex III subunit IV; cytochrome b-c1 complex subunit 4; ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit

NCBI Summary for CYC1

This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]

UniProt Comments for CYC1

CYC1: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. Belongs to the cytochrome c family.

Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: membrane; mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus

Molecular Function: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; iron ion binding; heme binding

Biological Process: cellular metabolic process; response to glucagon stimulus

Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 6

Research Articles on CYC1

1. HeLa cells expressing non-cleavable cytochrome c1 maintain mitochondrial morphology and functions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYC1 antibody

Reference Product	PubMed Publications
CYCS antibody	>1 publications with CYC1 and CYCS

Pathways associated with anti-CYC1 antibody

Products by Pathway	Pathway Diagram
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Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cytochrome Bc1 Complex Pathway antibodies	Cytochrome Bc1 Complex Pathway Diagram
Cytochrome Bc1 Complex Pathway antibodies	Cytochrome Bc1 Complex Pathway Diagram
Cytochrome Bc1 Complex Respiratory Unit Pathway antibodies	Cytochrome Bc1 Complex Respiratory Unit Pathway Diagram
Cytochrome Bc1 Complex Respiratory Unit Pathway antibodies	Cytochrome Bc1 Complex Respiratory Unit Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram

Diseases associated with anti-CYC1 antibody

Disease Name	Pubmed Publications
Drug Toxicity Antibodies	>5 publications with CYC1 and Drug Toxicity
Kidney Diseases Antibodies	>5 publications with CYC1 and Kidney Diseases
Nervous System Diseases Antibodies	>3 publications with CYC1 and Nervous System Diseases
Disease Models, Animal Antibodies	>3 publications with CYC1 and Disease Models, Animal
Brain Diseases Antibodies	>2 publications with CYC1 and Brain Diseases
Fatty Liver Antibodies	>2 publications with CYC1 and Fatty Liver
Ischemia Antibodies	>1 publications with CYC1 and Ischemia
Liver Diseases Antibodies	>1 publications with CYC1 and Liver Diseases
Fibrosis Antibodies	>1 publications with CYC1 and Fibrosis
Stroke Antibodies	>1 publications with CYC1 and Stroke

Organs/Tissues associated with anti-CYC1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>19 publications with CYC1 and Liver
Heart Antibodies	>12 publications with CYC1 and Heart
Muscle Antibodies	>8 publications with CYC1 and Muscle
Kidney Antibodies	>6 publications with CYC1 and Kidney
Blood Antibodies	>4 publications with CYC1 and Blood
Intestine Antibodies	>3 publications with CYC1 and Intestine
Brain Antibodies	>3 publications with CYC1 and Brain
Ovary Antibodies	>2 publications with CYC1 and Ovary
Ascites Antibodies	>1 publications with CYC1 and Ascites
Stomach Antibodies	>1 publications with CYC1 and Stomach