Cyclin Dependent Kinase 2 (CDK2) Antibody – Rabbit Polyclonal

CDK2: a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276

Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 7q11

Cellular Component: Cajal body; chromosome, telomeric region; condensed chromosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; endosome; intracellular membrane-bound organelle; microtubule organizing center; nucleoplasm; nucleus; transcription factor complex; X chromosome; Y chromosome

Molecular Function: ATP binding; cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; kinase activity; metal ion binding; protein complex binding; protein domain specific binding; protein kinase activity

Biological Process: cell division; cellular response to insulin stimulus; centriole replication; DNA repair; G1/S transition of mitotic cell cycle; histone phosphorylation; lens development in camera-type eye; meiotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; organ regeneration; peptidyl-serine phosphorylation; positive regulation of cell proliferation; positive regulation of DNA-dependent DNA replication initiation; positive regulation of transcription, DNA-templated; potassium ion transport; protein amino acid phosphorylation; Ras protein signal transduction; regulation of cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; response to cadmium ion; response to cAMP; response to drug; response to electrical stimulus; response to estradiol; response to ethanol; response to toxin; signal transduction