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DERL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625049

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DERL2, Polyclonal Antibody
Full Product Name
DERL2, CT (Derlin-2, Der1-like Protein 2, Degradation In Endoplasmic Reticulum Protein 2, DERtrin-2, F-LAN-1, F-LANa, SBBI53, CGI-101, FLANA, DER2)
Product Gene Name
anti-DERL2 antibody
Product Synonym Names
Anti -DERL2, CT (Derlin-2, Der1-like Protein 2, Degradation In Endoplasmic Reticulum Protein 2, DERtrin-2, F-LAN-1, F-LANa, SBBI53, CGI-101, FLANA, DER2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human DERL2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
27,567 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (5377613..5389497, complement). Location: 17p13.2
OMIM
610304
3D Structure
ModBase 3D Structure for Q9GZP9
Immunogen
Synthetic peptide selected from the C-terminal region of human DERL2 (KLH).

Product Categories/Family for anti-DERL2 antibody

Antibodies; Abs to Membrane Proteins
Applications Tested/Suitable for anti-DERL2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-DERL2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-DERL2 antibody

Western blot analysis of DERL2 Antibody (C-term) in MDA-MB231 cell line lysates (35ug/lane). DERL2 (arrow) was detected using the purified Pab.
Rabbit Anti-DERL2 Polyclonal Antibody – Cat# MBS625049

Immunohistochemistry (IHC) of anti-DERL2 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DERL2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-DERL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625049

Testing Data of anti-DERL2 antibody

DERL2 Antibody (C-term) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-DERL2 Polyclonal Antibody, Testing Data – Cat# MBS625049

Other Notes

Small volumes of anti-DERL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DERL2 purchase

MBS625049 is an antibody targeting DERL2. Also known as DERL2, CT (Derlin-2, Der1-like Protein 2, Degradation In Endoplasmic Reticulum Protein 2, DERtrin-2, F-LAN-1, F-LANa, SBBI53, CGI-101, FLANA, DER2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DERL2. It may not necessarily be applicable to this product.

NCBI GI #
31455614
NCBI GeneID
51009
NCBI Accession #
NP_057125.2
UniProt Primary Accession #
Q9GZP9
UniProt Secondary Accession #
Q9Y3A7
UniProt Related Accession #
Q9GZP9
GenBank Nucleotide #
NM_016041.3
NCBI Official Full Name
derlin-2
NCBI Official Synonym Full Names
Der1-like domain family, member 2
NCBI Official Symbol
DERL2
NCBI Official Synonym Symbols
FLANa; F-LANa; CGI-101; F-LAN-1
UniProt Protein Name
Derlin-2
UniProt Synonym Protein Names
Degradation in endoplasmic reticulum protein 2; DERtrin-2; Der1-like protein 2; F-LAN-1; F-LANa
Protein Family
Derlin
UniProt Gene Name
DERL2
UniProt Synonym Gene Names
DER2; FLANA
UniProt Entry Name
DERL2_HUMAN
NCBI Protein Information
derlin-2; DERtrin-2; carcinoma related; OTTHUMP00000128204; der1-like protein 2; degradation in endoplasmic reticulum protein 2

NCBI Summary for DERL2

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM]

UniProt Comments for DERL2

DERL2: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. Belongs to the derlin family.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; early endosome; late endosome; integral to endoplasmic reticulum membrane

Molecular Function: protein binding

Biological Process: retrograde protein transport, ER to cytosol; ER-associated protein catabolic process; suckling behavior; unfolded protein response; positive regulation of cell proliferation; positive regulation of cell growth
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Research Articles on DERL2

1. Required for Polyoma virus infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DERL2 antibody

 Products by Pathway  Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-DERL2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with DERL2 and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with DERL2 and Carcinoma, Hepatocellular
 Neoplasms Antibodies  >2 publications with DERL2 and Neoplasms
 Liver Diseases Antibodies  >1 publications with DERL2 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with DERL2 and Adenocarcinoma
 Fetal Death Antibodies  >1 publications with DERL2 and Fetal Death
 Neoplasms, Experimental Antibodies  >1 publications with DERL2 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >1 publications with DERL2 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with DERL2 and Liver Neoplasms

Organs/Tissues associated with anti-DERL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with DERL2 and Liver
 Blood Antibodies  >1 publications with DERL2 and Blood
 Kidney Antibodies  >1 publications with DERL2 and Kidney
 Embryonic Tissue Antibodies  >1 publications with DERL2 and Embryonic Tissue
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