• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

FCGR2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6298647

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in… More details

$1120 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FCGR2B, Polyclonal Antibody
Full Product Name
FCGR2B, CT (FCGR2B, CD32, FCG2, IGFR2, Low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc-gamma RII-b, CD32) (PE)
Product Gene Name
anti-FCGR2B antibody
Product Synonym Names
FCGR2B; CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc-gamma RII-b; CD32
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human FCGR2B.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
33,450 Da
OMIM
152700
3D Structure
ModBase 3D Structure for P31994
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 250-279 in the C-terminal region of human FCGR2B, UniProt Accession #P31994; NP_003992.3; NP_001002273.1; NP_001177757.1; NP_001002274.1
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-FCGR2B antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-FCGR2B antibody
Western Blot (WB), FLISA
Application Notes for anti-FCGR2B antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FCGR2B antibody

Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS6007452. This demonstrates that MBS6007452 detected the FCGR2B protein (arrow).
Rabbit Anti-FCGR2B Polyclonal Antibody – Cat# MBS6298647

Product References and Citations for anti-FCGR2B antibody

1. Prokopec, K.E., et al. Clin. Immunol. 137(3):322-329(2010). 2. Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010). 3. Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010). 4. Niederer, H.A., et al. Hum. Mol. Genet. 19(16):3282-3294(2010). 5. Guilabert, A., et al. J. Am. Acad. Dermatol. 63(1):161-163(2010).

Other Notes

Small volumes of anti-FCGR2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR2B purchase

MBS6298647 is an antibody targeting FCGR2B. Also known as FCGR2B, CT (FCGR2B, CD32, FCG2, IGFR2, Low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc-gamma RII-b, CD32) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR2B. It may not necessarily be applicable to this product.

NCBI GI #
50511930
NCBI GeneID
2213
NCBI Accession #
NP_003992.3
NCBI Related Accession #
NP_001002273.1; NP_001177757.1; NP_001002274.1
UniProt Primary Accession #
P31994
UniProt Secondary Accession #
O95649; Q53X85; Q5VXA9; Q8NIA1; A6H8N3
UniProt Related Accession #
P31994
GenBank Nucleotide #
NM_004001.4
NCBI Official Full Name
low affinity immunoglobulin gamma Fc region receptor II-b isoform 1
NCBI Official Synonym Full Names
Fc fragment of IgG, low affinity IIb, receptor (CD32)
NCBI Official Symbol
FCGR2B
NCBI Official Synonym Symbols
CD32; FCG2; CD32B; FCGR2; IGFR2
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-b
UniProt Synonym Protein Names
CDw32; Fc-gamma RII-b
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
FCGR2B
UniProt Synonym Gene Names
CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b
UniProt Entry Name
FCG2B_HUMAN
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; fcRII-b; Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD

UniProt Comments for FCGR2B

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Membrane protein, integral; Cell surface; Oncoprotein

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; IgG binding

Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction

Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To
Show more

Research Articles on FCGR2B

1. Data indicate that the lentiviral expression vector for FcgammaRIIB was successfully prepared and its expression in HT-1080 cells is controllable via the alterations of doxycycline (Dox) concentration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FCGR2B antibody

 Reference Product  PubMed Publications
 CRP antibody  >7 publications with FCGR2B and CRP
 LYN antibody  >2 publications with FCGR2B and LYN
 FCER1G antibody  >1 publications with FCGR2B and FCER1G
 PTPN11 antibody  >1 publications with FCGR2B and PTPN11
 PTPN6 antibody  >1 publications with FCGR2B and PTPN6

Pathways associated with anti-FCGR2B antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-FCGR2B antibody

 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >128 publications with FCGR2B and Autoimmune Diseases
 Lupus Erythematosus, Systemic Antibodies  >67 publications with FCGR2B and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >46 publications with FCGR2B and Inflammation
 Disease Models, Animal Antibodies  >44 publications with FCGR2B and Disease Models, Animal
 Kidney Diseases Antibodies  >26 publications with FCGR2B and Kidney Diseases
 Necrosis Antibodies  >17 publications with FCGR2B and Necrosis
 Nervous System Diseases Antibodies  >17 publications with FCGR2B and Nervous System Diseases
 Lung Diseases Antibodies  >13 publications with FCGR2B and Lung Diseases
 Skin Diseases Antibodies  >7 publications with FCGR2B and Skin Diseases
 Anemia Antibodies  >5 publications with FCGR2B and Anemia

Organs/Tissues associated with anti-FCGR2B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >178 publications with FCGR2B and Blood
 Spleen Antibodies  >28 publications with FCGR2B and Spleen
 Kidney Antibodies  >20 publications with FCGR2B and Kidney
 Bone Marrow Antibodies  >18 publications with FCGR2B and Bone Marrow
 Lymph Node Antibodies  >17 publications with FCGR2B and Lymph Node
 Brain Antibodies  >12 publications with FCGR2B and Brain
 Lung Antibodies  >8 publications with FCGR2B and Lung
 Liver Antibodies  >5 publications with FCGR2B and Liver
 Skin Antibodies  >3 publications with FCGR2B and Skin
 Connective Tissue Antibodies  >2 publications with FCGR2B and Connective Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000