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FRK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9208506

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FRK, Polyclonal Antibody
Full Product Name
FRK Antibody (N-term)
Product Gene Name
anti-FRK antibody
Product Synonym Names
Tyrosine-protein kinase FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; FRK; PTK5; RAK
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 2 (lot specific)
Specificity
This FRK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-44 amino acids from the N-terminal region of human FRK.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
FRK peptide (MBS9227185) is used for blocking the activity of FRK antibody (MBS9208506)
Molecular Weight
58254
Immunogen Sequence Positions
13-44
OMIM
606573
3D Structure
ModBase 3D Structure for P42685
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-FRK antibody

Cell Biology
Applications Tested/Suitable for anti-FRK antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-FRK antibody
WB~~1:1000

Western Blot (WB) of anti-FRK antibody

Western blot analysis of FRK (arrow) using rabbit polyclonal FRK Antibody (V28). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FRK gene.
Rabbit Anti-FRK Polyclonal Antibody – Cat# MBS9208506

Immunohistochemistry (IHC) of anti-FRK antibody

FRK Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FRK Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-FRK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9208506

Flow Cytometry (FC/FACS) of anti-FRK antibody

FRK Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-FRK Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9208506

Product References and Citations for anti-FRK antibody

Meyer, T., et al., Int. J. Cancer 104(2):139-146 (2003).
Craven, R.J., et al., Cancer Res. 55(18):3969-3972 (1995).
Cance, W.G., et al., Cell Growth Differ. 5(12):1347-1355 (1994).
Cance, W.G., et al., Int. J. Cancer 54(4):571-577 (1993).
Lee, J., et al., Gene 138 (1-2), 247-251 (1994).

Other Notes

Small volumes of anti-FRK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRK purchase

MBS9208506 is an antibody targeting FRK. Also known as FRK Antibody (N-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FRK. It may not necessarily be applicable to this product.

NCBI GI #
4503787
NCBI GeneID
2444
NCBI Accession #
NP_002022.1
UniProt Primary Accession #
P42685
UniProt Secondary Accession #
Q13128; Q9NTR5; B4DY49
UniProt Related Accession #
P42685
GenBank Nucleotide #
NM_002031.2
NCBI Official Full Name
tyrosine-protein kinase FRK
NCBI Official Synonym Full Names
fyn-related Src family tyrosine kinase
NCBI Official Symbol
FRK
NCBI Official Synonym Symbols
GTK; RAK; PTK5
UniProt Protein Name
Tyrosine-protein kinase FRK
UniProt Synonym Protein Names
FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5
Protein Family
Tyrosine-protein kinase
UniProt Gene Name
FRK
UniProt Synonym Gene Names
PTK5; RAK
UniProt Entry Name
FRK_HUMAN
NCBI Protein Information
tyrosine-protein kinase FRK

UniProt Comments for FRK

FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth.

Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; Tumor suppressor; EC 2.7.10.2; TK group; Src family

Chromosomal Location of Human Ortholog: 6q21-q22.3

Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; intracellular; nucleus

Molecular Function: protein binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: negative regulation of cell proliferation; cell migration; innate immune response; cell differentiation; actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
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Research Articles on FRK

1. exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FRK antibody

 Reference Product  PubMed Publications
 PTEN antibody  >4 publications with FRK and PTEN
 CSK antibody  >3 publications with FRK and CSK
 CRK antibody  >2 publications with FRK and CRK
 STAT3 antibody  >1 publications with FRK and STAT3

Diseases associated with anti-FRK antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >23 publications with FRK and Breast Neoplasms
 Adenocarcinoma Antibodies  >9 publications with FRK and Adenocarcinoma
 Nervous System Diseases Antibodies  >8 publications with FRK and Nervous System Diseases
 Ovarian Neoplasms Antibodies  >8 publications with FRK and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with FRK and Neoplasms, Experimental
 Vascular Diseases Antibodies  >5 publications with FRK and Vascular Diseases
 Liver Neoplasms Antibodies  >5 publications with FRK and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >5 publications with FRK and Cell Transformation, Neoplastic
 Necrosis Antibodies  >5 publications with FRK and Necrosis
 Carcinoma, Hepatocellular Antibodies  >4 publications with FRK and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-FRK antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >9 publications with FRK and Liver
 Prostate Antibodies  >7 publications with FRK and Prostate
 Pancreas Antibodies  >6 publications with FRK and Pancreas
 Mammary Gland Antibodies  >4 publications with FRK and Mammary Gland
 Placenta Antibodies  >3 publications with FRK and Placenta
 Connective Tissue Antibodies  >2 publications with FRK and Connective Tissue
 Ascites Antibodies  >1 publications with FRK and Ascites
 Bladder Antibodies  >1 publications with FRK and Bladder
 Testis Antibodies  >1 publications with FRK and Testis
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