FRK Antibody (N-Term) Blocking Peptide

Name: FRK Antibody (N-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9227185
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9227185

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FRK, Blocking Peptide

Full Product Name

FRK Antibody (N-term) Blocking Peptide

Product Gene Name

FRK blocking peptide

Product Synonym Gene Name

PTK5; RAK

Product Synonym Names

Tyrosine-protein kinase FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; FRK; PTK5; RAK

Form/Format

The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human FRK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

FRK peptide (MBS9227185) is used for blocking the activity of FRK antibody (MBS9208506)

Molecular Weight

41,980 Da

OMIM

606573

Cellular Location

Cytoplasm. Nucleus. Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery

Tissue Location

Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

Other Notes

Small volumes of FRK blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRK purchase

MBS9227185 is a blocking peptide targeting FRK. Also known as FRK Antibody (N-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for FRK. It may not necessarily be applicable to this product.

NCBI GI #

1169745

NCBI GeneID

2444

NCBI Accession #

P42685.1

UniProt Primary Accession #

P42685

UniProt Secondary Accession #

Q13128; Q9NTR5; B4DY49

UniProt Related Accession #

P42685

NCBI Official Full Name

Tyrosine-protein kinase FRK

NCBI Official Synonym Full Names

fyn related Src family tyrosine kinase

NCBI Official Symbol

FRK

NCBI Official Synonym Symbols

GTK; RAK; PTK5

UniProt Protein Name

Tyrosine-protein kinase FRK

UniProt Synonym Protein Names

FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5

Protein Family

Tyrosine-protein kinase

UniProt Gene Name

FRK

UniProt Synonym Gene Names

PTK5; RAK

UniProt Entry Name

FRK_HUMAN

NCBI Protein Information

tyrosine-protein kinase FRK

NCBI Summary for FRK

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

UniProt Comments for FRK

FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth.

Protein type: EC 2.7.10.2; Tumor suppressor; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Src family

Chromosomal Location of Human Ortholog: 6q21-q22.3

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; intracellular; intracellular membrane-bound organelle; nucleus

Molecular Function: protein binding; receptor binding

Biological Process: cell differentiation; innate immune response; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway

Research Articles on FRK

1. antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with FRK blocking peptide

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>23 publications with FRK and Breast Neoplasms
Adenocarcinoma Antibodies	>9 publications with FRK and Adenocarcinoma
Nervous System Diseases Antibodies	>9 publications with FRK and Nervous System Diseases
Ovarian Neoplasms Antibodies	>8 publications with FRK and Ovarian Neoplasms
Neoplasm Metastasis Antibodies	>6 publications with FRK and Neoplasm Metastasis
Vascular Diseases Antibodies	>6 publications with FRK and Vascular Diseases
Liver Neoplasms Antibodies	>6 publications with FRK and Liver Neoplasms
Cell Transformation, Neoplastic Antibodies	>5 publications with FRK and Cell Transformation, Neoplastic
Neoplasms, Experimental Antibodies	>5 publications with FRK and Neoplasms, Experimental
Liver Diseases Antibodies	>5 publications with FRK and Liver Diseases

Organs/Tissues associated with FRK blocking peptide

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>11 publications with FRK and Liver
Prostate Antibodies	>7 publications with FRK and Prostate
Pancreas Antibodies	>6 publications with FRK and Pancreas
Mammary Gland Antibodies	>4 publications with FRK and Mammary Gland
Placenta Antibodies	>3 publications with FRK and Placenta
Connective Tissue Antibodies	>2 publications with FRK and Connective Tissue
Ascites Antibodies	>1 publications with FRK and Ascites
Bladder Antibodies	>1 publications with FRK and Bladder
Testis Antibodies	>1 publications with FRK and Testis