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FUT6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9611776

Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.Similarity: Belongs to the glycosyltransferase 10 family. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FUT6, Polyclonal Antibody
Full Product Name
FUT6 Antibody
Product Gene Name
anti-FUT6 antibody
Product Synonym Names
FUT6 Antibody - N-terminal; Alpha (1,3) fucosyltransferase; EC=2.4.1.65; FCT3A; FT1A; Fuc TVI; fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Fucosyltransferase 6; Fucosyltransferase VI; FucT VI; Galactoside 3 L fucosyltransferase;
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Concentration
1mg/ml (lot specific)
Specificity
FUT6 Antibody detects endogenous levels of FUT6.
Preparation and Storage
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
FUT6 peptide (MBS9621729) is used for blocking the activity of FUT6 antibody (MBS9611776)
Molecular Weight
Observed Mol.Wt.: 45 kDa. Predicted Mol.Wt.: 42kDa.
OMIM
gene 613852
3D Structure
ModBase 3D Structure for P51993
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human FUT6.
Fragment
Fab fragment
Conjugation
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FUT6 antibody
Western Blot (WB)
Application Notes for anti-FUT6 antibody
WB 1:500-1:2000

Other Notes

Small volumes of anti-FUT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FUT6 purchase

MBS9611776 is an antibody targeting FUT6. Also known as FUT6 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FUT6. It may not necessarily be applicable to this product.

NCBI GI #
1730136
NCBI GeneID
2528
NCBI Accession #
P51993.1
UniProt Primary Accession #
P51993
UniProt Related Accession #
P51993
NCBI Official Full Name
Alpha-(1,3)-fucosyltransferase 6
NCBI Official Synonym Full Names
fucosyltransferase 6
NCBI Official Symbol
FUT6
NCBI Official Synonym Symbols
FT1A; FCT3A; Fuc-TVI; FucT-VI
UniProt Protein Name
Alpha-(1,3)-fucosyltransferase 6
UniProt Synonym Protein Names
Fucosyltransferase 6; Fucosyltransferase VI; Fuc-TVI; FucT-VI; Galactoside 3-L-fucosyltransferase
Protein Family
Alpha-(1,3)-fucosyltransferase
UniProt Gene Name
FUT6
UniProt Synonym Gene Names
FCT3A; Fuc-TVI; FucT-VI
UniProt Entry Name
FUT6_HUMAN
NCBI Protein Information
alpha-(1,3)-fucosyltransferase 6

NCBI Summary for FUT6

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FUT6

FUT6: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates. Belongs to the glycosyltransferase 10 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.4.1.65; Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi apparatus; integral to membrane

Molecular Function: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; alpha(1,3)-fucosyltransferase activity; fucosyltransferase activity

Biological Process: protein amino acid glycosylation; L-fucose catabolic process

Disease: Fucosyltransferase 6 Deficiency
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Research Articles on FUT6

1. we identified a novel association of a common loss-of-function, missense variant in Fucosyltransferase 6 (FUT6; rs17855739,p.Glu274Lys, P = 9.02 x 10-24) with higher soluble E-selectin levels. This variant is considerably more common in populations of African ancestry compared to non-African ancestry populations.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FUT6 antibody

 Reference Product  PubMed Publications
 FUT4 antibody  >15 publications with FUT6 and FUT4
 FUT2 antibody  >13 publications with FUT6 and FUT2
 FUT1 antibody  >11 publications with FUT6 and FUT1
 FUT9 antibody  >3 publications with FUT6 and FUT9
 ABO antibody  >3 publications with FUT6 and ABO

Pathways associated with anti-FUT6 antibody

 Products by Pathway  Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-FUT6 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >14 publications with FUT6 and Carcinoma
 Liver Neoplasms Antibodies  >7 publications with FUT6 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >6 publications with FUT6 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >6 publications with FUT6 and Liver Diseases
 Pancreatic Neoplasms Antibodies  >3 publications with FUT6 and Pancreatic Neoplasms
 Lung Neoplasms Antibodies  >2 publications with FUT6 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with FUT6 and Neoplasm Metastasis
 Hypertension Antibodies  >1 publications with FUT6 and Hypertension
 Prostatic Neoplasms Antibodies  >1 publications with FUT6 and Prostatic Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >1 publications with FUT6 and Leukemia, Myeloid, Acute

Organs/Tissues associated with anti-FUT6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >8 publications with FUT6 and Liver
 Brain Antibodies  >4 publications with FUT6 and Brain
 Kidney Antibodies  >3 publications with FUT6 and Kidney
 Stomach Antibodies  >2 publications with FUT6 and Stomach
 Prostate Antibodies  >2 publications with FUT6 and Prostate
 Intestine Antibodies  >2 publications with FUT6 and Intestine
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