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GLUD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9213200

The protein encoded by this gene is localized to themitochondrion and acts as a homohexamer to recycle glutamate duringneurotransmission. The encoded enzyme catalyzes the reversibleoxidative deamination of glutamate to alpha-ketoglutarate. Thisgene is… More details

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Product Overview

Online Datasheet in PDF
Product Name
GLUD2, Polyclonal Antibody
Full Product Name
GLUD2 Antibody (N-term)
Product Gene Name
Product Synonym Names
Glutamate dehydrogenase 2; mitochondrial; GDH 2; GLUD2; GLUDP1
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This GLUD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-103 amino acids from the N-terminal region of human GLUD2.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
GLUD2 peptide (MBS9228819) is used for blocking the activity of GLUD2 antibody (MBS9213200)
Molecular Weight
61434
Immunogen Sequence Positions
75-103
OMIM
300144
3D Structure
ModBase 3D Structure for P49448
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Applications Tested/Suitable for anti-GLUD2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-GLUD2 antibody
WB~~1:1000

Western Blot (WB) of anti-GLUD2 antibody

GLUD2 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the GLUD2 antibody detected the GLUD2 protein (arrow).
Rabbit Anti-GLUD2 Polyclonal Antibody – Cat# MBS9213200

Product References and Citations for anti-GLUD2 antibody

Spanaki, C., et al. J. Biol. Chem. 285(22):16748-16756(2010)
Plaitakis, A., et al. Eur. J. Hum. Genet. 18(3):336-341(2010)
Zaganas, I., et al. Neurochem. Int. 55 (1-3), 52-63 (2009) :
Mastorodemos, V., et al. Biochem. Cell Biol. 87(3):505-516(2009)
Kanavouras, K., et al. J. Neurochem. 109 SUPPL 1, 167-173 (2009) :

Other Notes

Small volumes of anti-GLUD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLUD2 purchase

MBS9213200 is an antibody targeting GLUD2. Also known as GLUD2 Antibody (N-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLUD2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
glutamate dehydrogenase 2, mitochondrial
NCBI Official Synonym Full Names
glutamate dehydrogenase 2
NCBI Official Symbol
GLUD2
NCBI Official Synonym Symbols
GDH2; GLUDP1
UniProt Protein Name
Glutamate dehydrogenase 2, mitochondrial
UniProt Gene Name
GLUD2
UniProt Synonym Gene Names
GLUDP1; GDH 2
UniProt Entry Name
DHE4_HUMAN
NCBI Protein Information
glutamate dehydrogenase 2, mitochondrial

NCBI Summary for GLUD2

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

UniProt Comments for GLUD2

GLUD2: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Homohexamer. Expressed in retina, testis and, at a lower level, brain. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Amino Acid Metabolism - arginine and proline; Oxidoreductase; Energy Metabolism - nitrogen; EC 1.4.1.3

Chromosomal Location of Human Ortholog: Xq24-q25

Cellular Component: mitochondrion; cytoplasm

Molecular Function: glutamate dehydrogenase activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; ADP binding

Biological Process: glutamate catabolic process; glutamate metabolic process; glutamate biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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