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GMPR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6302842

This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GMPR, Polyclonal Antibody
Full Product Name
GMPR, CT (GMPR, GMPR1, GMP reductase 1, Guanosine 5'-monophosphate oxidoreductase 1) (AP)
Product Gene Name
anti-GMPR antibody
Product Synonym Names
GMPR; GMPR1; GMP reductase 1; Guanosine 5'-monophosphate oxidoreductase 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
37,419 Da
OMIM
139265
3D Structure
ModBase 3D Structure for P36959
Immunogen
GMPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-267 amino acids from the C-terminal region of human GMPR.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-GMPR antibody

Antibodies; Enzymes; Reductase
Applications Tested/Suitable for anti-GMPR antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-GMPR antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:50-100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-GMPR antibody

Western blot analysis of GMPR (arrow) using rabbit polyclonal GMPR Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GMPR gene.
Rabbit Anti-GMPR Polyclonal Antibody – Cat# MBS6302842

Immunohistochemistry (IHC) of anti-GMPR antibody

GMPR Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GMPR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-GMPR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6302842

Product References and Citations for anti-GMPR antibody

Chasman, D.I., et al. PLoS Genet. 5 (11), E1000730 (2009): Lamesch, P., et al. Genomics 89(3):307-315(2007). Mungall, A.J., et al. Nature 425(6960):805-811(2003). Deng, Y., et al. Int. J. Biochem. Cell Biol. 34(9):1035-1050(2002). Salvatore, D., et al. J. Biol. Chem. 273(47):31092-31096(1998).

Other Notes

Small volumes of anti-GMPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GMPR purchase

MBS6302842 is an antibody targeting GMPR. Also known as GMPR, CT (GMPR, GMPR1, GMP reductase 1, Guanosine 5'-monophosphate oxidoreductase 1) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GMPR. It may not necessarily be applicable to this product.

NCBI GI #
156104880
NCBI GeneID
2766
NCBI Accession #
NP_006868.3
UniProt Primary Accession #
P36959
UniProt Secondary Accession #
Q96HQ6
UniProt Related Accession #
P36959
GenBank Nucleotide #
NM_006877.3
NCBI Official Full Name
GMP reductase 1
NCBI Official Synonym Full Names
guanosine monophosphate reductase
NCBI Official Symbol
GMPR
NCBI Official Synonym Symbols
GMPR1
UniProt Protein Name
GMP reductase 1
UniProt Synonym Protein Names
Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1
Protein Family
GMP reductase
UniProt Gene Name
GMPR
UniProt Synonym Gene Names
GMPR1; Guanosine monophosphate reductase 1
UniProt Entry Name
GMPR1_HUMAN
NCBI Protein Information
GMP reductase 1; guanine monophosphate reductase; guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase 1

UniProt Comments for GMPR

GMPR: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family.

Protein type: Nucleotide Metabolism - purine; Oxidoreductase; EC 1.7.1.7

Chromosomal Location of Human Ortholog: 6p23

Cellular Component: cytosol

Molecular Function: GMP reductase activity; metal ion binding

Biological Process: nucleobase, nucleoside and nucleotide metabolic process; nucleotide metabolic process; response to cold; purine base metabolic process; purine salvage
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Research Articles on GMPR

1. GMPR as a suppressor of melanoma invasion is downregulated at the early invasive stages of melanoma progression and whose activity inhibits melanoma cell invasion by depleting intracellular GTP pools.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GMPR antibody

 Reference Product  PubMed Publications
 IMPDH2 antibody  >2 publications with GMPR and IMPDH2
 AMPD2 antibody  >1 publications with GMPR and AMPD2
 AMPD3 antibody  >1 publications with GMPR and AMPD3
 IMPDH1 antibody  >1 publications with GMPR and IMPDH1

Pathways associated with anti-GMPR antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Salvage Pathway antibodies  Purine Salvage Pathway Diagram

Diseases associated with anti-GMPR antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2 publications with GMPR and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with GMPR and Heart Diseases
 Nervous System Diseases Antibodies  >1 publications with GMPR and Nervous System Diseases

Organs/Tissues associated with anti-GMPR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with GMPR and Blood
 Heart Antibodies  >2 publications with GMPR and Heart
 Eye Antibodies  >1 publications with GMPR and Eye
 Nerve Antibodies  >1 publications with GMPR and Nerve
 Brain Antibodies  >1 publications with GMPR and Brain
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