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GREM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6006977

Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells. More details

$970 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GREM2, Polyclonal Antibody
Full Product Name
GREM2 (Gremlin-2, Cysteine Knot Superfamily 1, BMP Antagonist 2, DAN Domain Family Member 3, Protein Related to DAN and Cerberus, CKTSF1B2, DAND3, PRDC, FLJ21195)
Product Gene Name
Product Synonym Names
Anti -GREM2 (Gremlin-2, Cysteine Knot Superfamily 1, BMP Antagonist 2, DAN Domain Family Member 3, Protein Related to DAN and Cerberus, CKTSF1B2, DAND3, PRDC, FLJ21195)
Immunogen Sequence
MFWKLSLSLF MVAVLVKVAE ARKNRPAGAI HSPYKDGSSN NSERWQHQIK EVLASSQEAL VVTERKYLKS DWCKTQPLRQ TVSEEGCRSR TILNRFCYGQ CNSFYIPRHV KKEEESFQSC AFCKPQRVTS VLVELECPGL DPPFRLKKIQ KVKQCRCMSV NLSDSDKQ
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid.
Purity/Purification
Serum
Serum
Specificity
Recognizes human GREM2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
19,320 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (240652873..240775462, complement). Location: 1q43
OMIM
608832
3D Structure
ModBase 3D Structure for Q9H772
Immunogen
Full length human GREM2, aa1-168 (AAH46632.1).
Applications Tested/Suitable for anti-GREM2 antibody
Immunoprecipitation (IP)
Application Notes for anti-GREM2 antibody
Suitable for use in Immunoprecipitation.

Immunoprecipitation (IP) of anti-GREM2 antibody

Immunoprecipitation of GREM2 transfected lysate using MBS6006977 and Protein A Magnetic Bead and immunoblotted with MBS6006977.
Rabbit Anti-GREM2 Polyclonal Antibody – Cat# MBS6006977

Other Notes

Small volumes of anti-GREM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GREM2 purchase

MBS6006977 is an antibody targeting GREM2. Also known as GREM2 (Gremlin-2, Cysteine Knot Superfamily 1, BMP Antagonist 2, DAN Domain Family Member 3, Protein Related to DAN and Cerberus, CKTSF1B2, DAND3, PRDC, FLJ21195). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GREM2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
gremlin-2
NCBI Official Synonym Full Names
gremlin 2, DAN family BMP antagonist
NCBI Official Symbol
GREM2
NCBI Official Synonym Symbols
PRDC; DAND3; CKTSF1B2
UniProt Protein Name
Gremlin-2
UniProt Synonym Protein Names
Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus
Protein Family
UniProt Gene Name
GREM2
UniProt Synonym Gene Names
CKTSF1B2; DAND3; PRDC
UniProt Entry Name
GREM2_HUMAN
NCBI Protein Information
gremlin-2; DAN domain family member 3; protein related to DAN and cerberus; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog

NCBI Summary for GREM2

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
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UniProt Comments for GREM2

GREM2: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells. Belongs to the DAN family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; protein homodimerization activity; cytokine activity

Biological Process: BMP signaling pathway; embryonic body morphogenesis; cytokine and chemokine mediated signaling pathway; determination of dorsal identity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GREM2 antibody

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