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IMMP2L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9148397

This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IMMP2L, Polyclonal Antibody
Full Product Name
IMMP2L Rabbit pAb
Product Gene Name
anti-IMMP2L antibody
Product Synonym Names
IMMP2L; IMMP2L-IT1; IMP2; IMP2-LIKE; mitochondrial inner membrane protease subunit 2
Immunogen Sequence
TFLDRVACVA RVEGASMQPS LNPGGSQSSD VVLLNHWKVR NFEVHRGDIV SLVSPKNPEQ KIIKRVIALE GDIVRTIGHK NRYVKVPRGH IWVEGDHHGH SFDSNSFGPV SLGLLHAHAT HILWPPERWQ KLESVLPPER LPVQREEE
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
Calculated MW: 12kDa/19kDa
Observed MW: 20kDa
OMIM
137580
3D Structure
ModBase 3D Structure for Q96T52
Cross Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 38-175 of human IMMP2L(NP_001231535.1).

Product Categories/Family for anti-IMMP2L antibody

Cancer; Signal Transduction; Cell Biology & Developmental Biology; Ubiquitin; Endocrine & Metabolism; Mitochondrial metabolism; Mitochondrial markers; Antibodies
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IMMP2L antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-IMMP2L antibody
WB: 1:500-1:1000
IF/ICC: 1:50-1:200
ELISA: Recommended starting concentration is 1ug/mL.
Please optimize the concentration based on your specific assay requirements.

Western Blot (WB) of anti-IMMP2L antibody

Western blot analysis of various lysates using IMMP2L Rabbit pAb (MBS9148397) at 1:700 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates / proteins: 25 ug per lane.
Blocking buffer: 3 % nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (RM00021).
Exposure time: 60s.
Rabbit Anti-IMMP2L Polyclonal Antibody – Cat# MBS9148397

Immunofluorescence (IF) of anti-IMMP2L antibody

Immunofluorescence analysis of NIH/3T3 cells using IMMP2L Rabbit pAb (MBS9148397) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Rabbit Anti-IMMP2L Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9148397

Other Notes

Small volumes of anti-IMMP2L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IMMP2L purchase

MBS9148397 is an antibody targeting IMMP2L. Also known as IMMP2L Rabbit pAb. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IMMP2L. It may not necessarily be applicable to this product.

NCBI GI #
347446661
NCBI GeneID
83943
NCBI Accession #
NP_001231535.1
UniProt Primary Accession #
Q96T52
UniProt Secondary Accession #
Q75MF1; Q75MN9; Q75MP0; Q75MS5; Q75MS8; Q96HJ2
UniProt Related Accession #
Q96T52
GenBank Nucleotide #
NM_001244606.1
UniProt Protein Name
Mitochondrial inner membrane protease subunit 2
UniProt Synonym Protein Names
IMP2-like protein
UniProt Gene Name
IMMP2L
UniProt Entry Name
IMP2L_HUMAN

UniProt Comments for IMMP2L

IMMP2L: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. Defects in IMMP2L may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Belongs to the peptidase S26 family. IMP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Membrane protein, integral; Mitochondrial; Protease

Chromosomal Location of Human Ortholog: 7q31

Molecular Function: peptidase activity; serine-type endopeptidase activity

Biological Process: mitochondrial protein processing; mitochondrial respiratory chain complex assembly; signal peptide processing
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IMMP2L antibody

 Products by Pathway  Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram

Diseases associated with anti-IMMP2L antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with IMMP2L and Nervous System Diseases
 Autistic Disorder Antibodies  >7 publications with IMMP2L and Autistic Disorder
 Chromosome Aberrations Antibodies  >5 publications with IMMP2L and Chromosome Aberrations
 Disease Models, Animal Antibodies  >4 publications with IMMP2L and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >4 publications with IMMP2L and Neurobehavioral Manifestations
 Infertility, Male Antibodies  >3 publications with IMMP2L and Infertility, Male
 Infertility, Female Antibodies  >3 publications with IMMP2L and Infertility, Female
 Congenital Abnormalities Antibodies  >3 publications with IMMP2L and Congenital Abnormalities
 Breast Neoplasms Antibodies  >2 publications with IMMP2L and Breast Neoplasms
 Learning Disorders Antibodies  >2 publications with IMMP2L and Learning Disorders

Organs/Tissues associated with anti-IMMP2L antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with IMMP2L and Brain
 Kidney Antibodies  >2 publications with IMMP2L and Kidney
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