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IRF3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8248309

MBS8248309 is an antibody targeting IRF3. Reactive in Human. Host: Rabbit. Rabbit polyclonal antibody to IRF3 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IRF3, Polyclonal Antibody
Full Product Name
Anti-IRF3 Antibody
Product Gene Name
anti-IRF3 antibody
Product Synonym Names
Interferon regulatory factor 3; IRF-3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by affinity chromatography.
Specificity
Recognizes endogenous levels of IRF3 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
IRF3 peptide (MBS8248021) is used for blocking the activity of IRF3 antibody (MBS8248309)
Molecular Weight
12,330 Da
OMIM
603734
3D Structure
ModBase 3D Structure for Q14653
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IRF3. The exact sequence is proprietary.
Applications Tested/Suitable for anti-IRF3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IRF3 antibody
WB: 1/500 - 1/2000; Immunohistochemistry: 1/50 - 1/200

Western Blot (WB) of anti-IRF3 antibody

Western blot analysis of IRF3 expression in Hela (A) whole cell lysates.
Rabbit Anti-IRF3 Polyclonal Antibody – Cat# MBS8248309

Immunohistochemistry (IHC) of anti-IRF3 antibody

Immunohistochemical analysis of IRF3 staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-IRF3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS8248309

Other Notes

Small volumes of anti-IRF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF3. It may not necessarily be applicable to this product.

NCBI GI #
308199446
NCBI GeneID
3661
NCBI Accession #
NP_001184051.1
UniProt Primary Accession #
Q14653
UniProt Secondary Accession #
Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6; A8K7L2; B2RAZ3
UniProt Related Accession #
Q14653
GenBank Nucleotide #
NM_001197122.1
NCBI Official Full Name
interferon regulatory factor 3 isoform 2
NCBI Official Synonym Full Names
interferon regulatory factor 3
NCBI Official Symbol
IRF3
NCBI Official Synonym Symbols
IIAE7
UniProt Protein Name
Interferon regulatory factor 3
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF3
UniProt Synonym Gene Names
IRF-3
UniProt Entry Name
IRF3_HUMAN
NCBI Protein Information
interferon regulatory factor 3

NCBI Summary for IRF3

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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UniProt Comments for IRF3

IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; transcription cofactor activity

Biological Process: apoptosis; defense response to virus; negative regulation of interferon type I production; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; response to DNA damage stimulus; transcription from RNA polymerase II promoter

Disease: Herpes Simplex Encephalitis, Susceptibility To, 7
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Research Articles on IRF3

1. FAF1 plays a novel role in negatively regulating virus-induced IFN-beta production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 from the cytosol to the nucleus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRF3 antibody

 Reference Product  PubMed Publications
 TBK1 antibody  >315 publications with IRF3 and TBK1
 JUN antibody  >180 publications with IRF3 and JUN
 MAVS antibody  >141 publications with IRF3 and MAVS
 RELA antibody  >38 publications with IRF3 and RELA
 ATF2 antibody  >15 publications with IRF3 and ATF2
 CREBBP antibody  >15 publications with IRF3 and CREBBP
 IFIT1 antibody  >7 publications with IRF3 and IFIT1
 TMEM173 antibody  >6 publications with IRF3 and TMEM173
 EP300 antibody  >6 publications with IRF3 and EP300
 UBC antibody  >1 publications with IRF3 and UBC

Pathways associated with anti-IRF3 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram

Diseases associated with anti-IRF3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >254 publications with IRF3 and Inflammation
 Necrosis Antibodies  >176 publications with IRF3 and Necrosis
 Liver Diseases Antibodies  >79 publications with IRF3 and Liver Diseases
 Cardiovascular Diseases Antibodies  >36 publications with IRF3 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >30 publications with IRF3 and Kidney Diseases
 Carcinoma Antibodies  >25 publications with IRF3 and Carcinoma
 Neoplasms, Experimental Antibodies  >11 publications with IRF3 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >10 publications with IRF3 and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >9 publications with IRF3 and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >9 publications with IRF3 and Fibrosis

Organs/Tissues associated with anti-IRF3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >232 publications with IRF3 and Blood
 Liver Antibodies  >95 publications with IRF3 and Liver
 Kidney Antibodies  >72 publications with IRF3 and Kidney
 Bone Antibodies  >68 publications with IRF3 and Bone
 Lung Antibodies  >64 publications with IRF3 and Lung
 Brain Antibodies  >54 publications with IRF3 and Brain
 Spleen Antibodies  >40 publications with IRF3 and Spleen
 Skin Antibodies  >35 publications with IRF3 and Skin
 Muscle Antibodies  >23 publications with IRF3 and Muscle
 Intestine Antibodies  >19 publications with IRF3 and Intestine
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