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ISPD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7046434

Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation. More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ISPD, Polyclonal Antibody
Full Product Name
ISPD Antibody
Product Gene Name
anti-ISPD antibody
Product Synonym Names
Isoprenoid synthase domain-containing protein; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; ISPD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: ISPD (MBS7046434)
HRP Conjugated Antibody: ISPD (MBS7045621)
Matching Pairs
Unconjugated Antibody: ISPD (MBS7046434)
Biotin Conjugated Antibody: ISPD (MBS7045712)
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Molecular Weight
44,389 Da
OMIM
614631
3D Structure
ModBase 3D Structure for A4D126
Species
Human
Immunogen
Recombinant human Isoprenoid synthase domain-containing protein
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ISPD antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-ISPD antibody

Immunohistochemistry of paraffin-embedded human liver cancer using MBS7046434 at dilution of 1:100
Rabbit Anti-ISPD Polyclonal Antibody – Cat# MBS7046434

Immunohistochemistry (IHC) of anti-ISPD antibody

Immunohistochemistry of paraffin-embedded human testis tissue using MBS7046434 at dilution of 1:100
Rabbit Anti-ISPD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7046434

Immunohistochemistry (IHC) of anti-ISPD antibody

Immunofluorescent analysis of HepG2 cells using MBS7046434 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Rabbit Anti-ISPD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7046434

Other Notes

Small volumes of anti-ISPD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ISPD purchase

MBS7046434 is an antibody targeting ISPD. Also known as ISPD Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ISPD. It may not necessarily be applicable to this product.

NCBI GI #
157671913
NCBI GeneID
729920
NCBI Accession #
NP_001094887.1
UniProt Primary Accession #
A4D126
UniProt Secondary Accession #
A8MU35; H9KVB2
UniProt Related Accession #
A4D126
GenBank Nucleotide #
NM_001101417.3
NCBI Official Full Name
isoprenoid synthase domain-containing protein isoform b
NCBI Official Synonym Full Names
isoprenoid synthase domain containing
NCBI Official Symbol
ISPD
NCBI Official Synonym Symbols
Nip; MDDGA7; MDDGC7; hCG_1745121
UniProt Protein Name
Isoprenoid synthase domain-containing protein
UniProt Synonym Protein Names
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein
Protein Family
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
UniProt Gene Name
ISPD
UniProt Entry Name
ISPD_HUMAN
NCBI Protein Information
isoprenoid synthase domain-containing protein

NCBI Summary for ISPD

This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

UniProt Comments for ISPD

ISPD: Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation. Defects in ISPD are the cause of muscular dystrophy- dystroglycanopathy congenital with brain and eye anomalies type A7 (MDDGA7). MDDGA7 is an autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye- brain disease. Belongs to the IspD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.-; Transferase

Chromosomal Location of Human Ortholog: 7p21.2

Biological Process: protein amino acid O-linked mannosylation

Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 7; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 7
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Research Articles on ISPD

1. data suggest that the genetic heterogeneity of Limb Girdle Muscular Dystrophy with and without alpha-DG defects is greater than previously realized.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ISPD antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >15 publications with ISPD and Kidney Diseases
 Muscular Diseases Antibodies  >11 publications with ISPD and Muscular Diseases
 Congenital Abnormalities Antibodies  >8 publications with ISPD and Congenital Abnormalities
 Walker-Warburg Syndrome Antibodies  >7 publications with ISPD and Walker-Warburg Syndrome
 Nervous System Malformations Antibodies  >6 publications with ISPD and Nervous System Malformations
 Eye Abnormalities Antibodies  >5 publications with ISPD and Eye Abnormalities
 Hydrocephalus Antibodies  >3 publications with ISPD and Hydrocephalus
 Neurologic Manifestations Antibodies  >3 publications with ISPD and Neurologic Manifestations
 Hypertrophy Antibodies  >2 publications with ISPD and Hypertrophy
 Chromosome Aberrations Antibodies  >2 publications with ISPD and Chromosome Aberrations

Organs/Tissues associated with anti-ISPD antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with ISPD and Brain
 Muscle Antibodies  >13 publications with ISPD and Muscle
 Blood Antibodies  >11 publications with ISPD and Blood
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