• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

JAM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6311547

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JAM2, Polyclonal Antibody
Full Product Name
JAM2, NT (JAM2, C21orf43, VEJAM, Junctional adhesion molecule B, Junctional adhesion molecule 2, Vascular endothelial junction-associated molecule, CD322) (Azide free) (HRP)
Product Gene Name
anti-JAM2 antibody
Product Synonym Names
JAM2; C21orf43; VEJAM; Junctional adhesion molecule B; Junctional adhesion molecule 2; Vascular endothelial junction-associated molecule; CD322
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human JAM2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,554 Da
OMIM
606870
3D Structure
ModBase 3D Structure for P57087
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 63-91 in the N-termional region of human JAM2, UniProt Accession #P57087.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-JAM2 antibody

Antibodies; Connexin; Junction Proteins
Applications Tested/Suitable for anti-JAM2 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-JAM2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-JAM2 antibody

Western Blot analysis of CEM cell line lysates (35ug/lane) usingMBS6007707. This demonstrates that MBS6007707 detected the JAM2 protein (arrow).
Rabbit Anti-JAM2 Polyclonal Antibody – Cat# MBS6311547

Western Blot (WB) of anti-JAM2 antibody

Western Blot analysis of lysate from A431 cell line (35ug(, using MBS6007707 (1:1000). A goat anti-rabbit IgG H&L(HRP) at 1:5,000 was used as the secondary antibody.
Rabbit Anti-JAM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6311547

Immunohistochemistry (IHC) of anti-JAM2 antibody

Immunohistochemistry analysis of formalin fixed and paraffin embedded human placenta tissue using MBS6007707 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6007707 for immunohistochemistry.
Rabbit Anti-JAM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6311547

Product References and Citations for anti-JAM2 antibody

Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Ueki, T., et al. Microvasc. Res. 75(2):269-278(2008). Weber, C., et al. Nat. Rev. Immunol. 7(6):467-477(2007 Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005). Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004).

Other Notes

Small volumes of anti-JAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JAM2 purchase

MBS6311547 is an antibody targeting JAM2. Also known as JAM2, NT (JAM2, C21orf43, VEJAM, Junctional adhesion molecule B, Junctional adhesion molecule 2, Vascular endothelial junction-associated molecule, CD322) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JAM2. It may not necessarily be applicable to this product.

NCBI GI #
10864029
NCBI GeneID
58494
NCBI Accession #
NP_067042.1
UniProt Primary Accession #
P57087
UniProt Secondary Accession #
Q6UXG6; Q6YNC1; B2R6T9; B4DGT9
UniProt Related Accession #
P57087
GenBank Nucleotide #
NM_021219.3
NCBI Official Full Name
junctional adhesion molecule B isoform 1
NCBI Official Synonym Full Names
junctional adhesion molecule 2
NCBI Official Symbol
JAM2
NCBI Official Synonym Symbols
JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
UniProt Protein Name
Junctional adhesion molecule B
UniProt Synonym Protein Names
Junctional adhesion molecule 2; JAM-2; Vascular endothelial junction-associated molecule
Protein Family
Junctional adhesion molecule
UniProt Gene Name
JAM2
UniProt Synonym Gene Names
C21orf43; VEJAM; JAM-B; JAM-2; VE-JAM
UniProt Entry Name
JAM2_HUMAN
NCBI Protein Information
junctional adhesion molecule B; JAM-2; JAM-IT/VE-JAM; vascular endothelial junction-associated molecule

NCBI Summary for JAM2

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Show more

UniProt Comments for JAM2

JAM2: May play a role in the processes of lymphocyte homing to secondary lymphoid organs. Belongs to the immunoglobulin superfamily.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q21.2

Cellular Component: tight junction; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; protein heterodimerization activity

Biological Process: extracellular matrix organization and biogenesis; cell-cell adhesion; negative regulation of cell adhesion; blood coagulation; leukocyte migration
Show more

Research Articles on JAM2

1. These data brought new evidences for the role of JAM2 and JAM3 in progression of gastric adenocarcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JAM2 antibody

 Reference Product  PubMed Publications
 JAM3 antibody  >22 publications with JAM2 and JAM3
 ITGA4 antibody  >1 publications with JAM2 and ITGA4
 TJP1 antibody  >1 publications with JAM2 and TJP1

Pathways associated with anti-JAM2 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram

Diseases associated with anti-JAM2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with JAM2 and Inflammation
 Nervous System Diseases Antibodies  >2 publications with JAM2 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >2 publications with JAM2 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >2 publications with JAM2 and Neoplasms, Experimental
 Neurobehavioral Manifestations Antibodies  >1 publications with JAM2 and Neurobehavioral Manifestations
 Adenocarcinoma Antibodies  >1 publications with JAM2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >1 publications with JAM2 and Breast Neoplasms
 Infertility, Male Antibodies  >1 publications with JAM2 and Infertility, Male
 Necrosis Antibodies  >1 publications with JAM2 and Necrosis

Organs/Tissues associated with anti-JAM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with JAM2 and Brain
 Embryonic Tissue Antibodies  >6 publications with JAM2 and Embryonic Tissue
 Lung Antibodies  >6 publications with JAM2 and Lung
 Eye Antibodies  >3 publications with JAM2 and Eye
 Testis Antibodies  >3 publications with JAM2 and Testis
 Kidney Antibodies  >3 publications with JAM2 and Kidney
 Nerve Antibodies  >3 publications with JAM2 and Nerve
 Ear Antibodies  >2 publications with JAM2 and Ear
 Heart Antibodies  >2 publications with JAM2 and Heart
 Tonsil Antibodies  >2 publications with JAM2 and Tonsil
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000