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M6PR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648118

The protein encoded by this gene is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
M6PR, Polyclonal Antibody
Full Product Name
M6PR, CT (M6PR, MPR46, MPRD, Cation-dependent mannose-6-phosphate receptor, 46kD mannose 6-phosphate receptor)
Product Gene Name
anti-M6PR antibody
Product Synonym Names
Anti -M6PR, CT (M6PR, MPR46, MPRD, Cation-dependent mannose-6-phosphate receptor, 46kD mannose 6-phosphate receptor)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
30,975 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (9092957..9102357, complement). Location: 12p13
3D Structure
ModBase 3D Structure for Q6I9U3
Immunogen
M6PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-268 amino acids from the C-terminal region of human M6PR.

Product Categories/Family for anti-M6PR antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-M6PR antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-M6PR antibody
Suitable for use in Western Blot, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Flow Cytometry: 1:10-50
Immunofluorescence: 1:10-50

Western Blot (WB) of anti-M6PR antibody

M6PR Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the M6PR antibody detected the M6PR protein (arrow).
Rabbit Anti-M6PR Polyclonal Antibody – Cat# MBS648118

Flow Cytometry (FC/FACS) of anti-M6PR antibody

M6PR Antibody (C-term) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-M6PR Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS648118

Immunofluorescence (IF) of anti-M6PR antibody

Confocal immunofluorescent analysis of M6PR Antibody (C-term)(AP2792b) with A549 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-M6PR Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS648118

Other Notes

Small volumes of anti-M6PR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for M6PR purchase

MBS648118 is an antibody targeting M6PR. Also known as M6PR, CT (M6PR, MPR46, MPRD, Cation-dependent mannose-6-phosphate receptor, 46kD mannose 6-phosphate receptor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for M6PR. It may not necessarily be applicable to this product.

NCBI GI #
48146941
NCBI GeneID
4074
NCBI Accession #
CAG33693.1
UniProt Primary Accession #
Q6I9U3
UniProt Related Accession #
P20645
NCBI Official Full Name
M6PR
NCBI Official Synonym Full Names
mannose-6-phosphate receptor (cation dependent)
NCBI Official Symbol
M6PR
NCBI Official Synonym Symbols
SMPR; MPR46; CD-MPR; MPR 46; MPR-46
UniProt Protein Name
M6PR protein
Protein Family
Cation-dependent mannose-6-phosphate receptor
UniProt Gene Name
M6PR
UniProt Entry Name
Q6I9U3_HUMAN
NCBI Protein Information
cation-dependent mannose-6-phosphate receptor; Mr 46,000 Man6PR; CD Man-6-P receptor; small mannose 6-phosphate receptor; 46-kDa mannose 6-phosphate receptor

NCBI Summary for M6PR

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
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UniProt Comments for M6PR

M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: membrane; lysosomal membrane; integral to plasma membrane; perinuclear region of cytoplasm; late endosome; endosome

Molecular Function: mannose transmembrane transporter activity; mannose binding; transmembrane receptor activity

Biological Process: receptor-mediated endocytosis; endosome to lysosome transport; signal transduction; mannose transport
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Research Articles on M6PR

1. Sortilin is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR is able to internalize circulating alpha-Gal A.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-M6PR antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Vesicle Biogenesis Pathway antibodies  Lysosome Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Organs/Tissues associated with anti-M6PR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with M6PR and Blood
 Brain Antibodies  >9 publications with M6PR and Brain
 Muscle Antibodies  >9 publications with M6PR and Muscle
 Liver Antibodies  >8 publications with M6PR and Liver
 Lung Antibodies  >6 publications with M6PR and Lung
 Kidney Antibodies  >6 publications with M6PR and Kidney
 Vascular Antibodies  >5 publications with M6PR and Vascular
 Embryonic Tissue Antibodies  >5 publications with M6PR and Embryonic Tissue
 Heart Antibodies  >4 publications with M6PR and Heart
 Nerve Antibodies  >3 publications with M6PR and Nerve
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