MIRK Antibody – Rabbit Polyclonal

DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain. [provided by RefSeq, Jul 2008]

DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.

Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor); CMGC group; DYRK family; Dyrk1 subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transcription coactivator activity; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; myoblast fusion

Disease: Abdominal Obesity-metabolic Syndrome 3