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MAP3K10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629953

MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MLK2 (MAP3K10), Polyclonal Antibody
Full Product Name
MLK2, CT (Mixed Lineage Kinase 2, Mitogen-activated Protein Kinase Kinase Kinase 10, MAP3K10, MEKK10, MST, Protein Kinase MST)
Product Gene Name
anti-MAP3K10 antibody
Product Synonym Names
Anti -MLK2, CT (Mixed Lineage Kinase 2, Mitogen-activated Protein Kinase Kinase Kinase 10, MAP3K10, MEKK10, MST, Protein Kinase MST)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human MLK2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
103,694 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (40697504..40721487). Location: 19q13.2
OMIM
600137
3D Structure
ModBase 3D Structure for Q02779
Immunogen
Synthetic peptide selected from the C-terminal region of human MLK2 (KLH).

Product Categories/Family for anti-MAP3K10 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-MAP3K10 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MAP3K10 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-MAP3K10 antibody

The anti-MLK2 Pab is used in Western blot to detect MLK2 in transfected COS7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX).
Rabbit Anti-MAP3K10 Polyclonal Antibody – Cat# MBS629953

Immunohistochemistry (IHC) of anti-MAP3K10 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-MAP3K10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629953

Other Notes

Small volumes of anti-MAP3K10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAP3K10 purchase

MBS629953 is an antibody targeting MAP3K10. Also known as MLK2, CT (Mixed Lineage Kinase 2, Mitogen-activated Protein Kinase Kinase Kinase 10, MAP3K10, MEKK10, MST, Protein Kinase MST). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAP3K10. It may not necessarily be applicable to this product.

NCBI GI #
21735550
NCBI GeneID
4294
NCBI Accession #
NP_002437.2
UniProt Primary Accession #
Q02779
UniProt Secondary Accession #
Q12761; Q14871
UniProt Related Accession #
Q02779
GenBank Nucleotide #
NM_002446.3
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase 10
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase 10
NCBI Official Symbol
MAP3K10
NCBI Official Synonym Symbols
MST; MLK2; MEKK10
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase 10
UniProt Synonym Protein Names
Mixed lineage kinase 2; Protein kinase MST
Protein Family
Mitogen-activated protein kinase kinase kinase
UniProt Gene Name
MAP3K10
UniProt Synonym Gene Names
MLK2; MST
UniProt Entry Name
M3K10_HUMAN
NCBI Protein Information
mitogen-activated protein kinase kinase kinase 10; MKN28 kinase; protein kinase MST; mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase

NCBI Summary for MAP3K10

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for MAP3K10

MLK2: a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.25; TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein homodimerization activity; JUN kinase kinase kinase activity; bHLH transcription factor binding; transcription corepressor activity; ATP binding; protein kinase activity

Biological Process: positive regulation of JNK activity; smoothened signaling pathway; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; negative regulation of transcription factor activity; peptidyl-threonine phosphorylation; positive regulation of JNK cascade; signal transduction; activation of JNK activity; peptidyl-serine phosphorylation; JNK cascade; negative regulation of transcription, DNA-dependent; activation of JNKK activity
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Research Articles on MAP3K10

1. A novel and important role for MAP3K10 in the proliferation and chemoresistance of pancreatic ductal adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAP3K10 antibody

 Reference Product  PubMed Publications
 CDC42 antibody  >4 publications with MAP3K10 and CDC42
 MAP2K4 antibody  >3 publications with MAP3K10 and MAP2K4
 RAC1 antibody  >1 publications with MAP3K10 and RAC1
 MAP2K6 antibody  >1 publications with MAP3K10 and MAP2K6
 MAP2K3 antibody  >1 publications with MAP3K10 and MAP2K3
 HTT antibody  >1 publications with MAP3K10 and HTT

Pathways associated with anti-MAP3K10 antibody

 Products by Pathway  Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 P38 MAPK Signaling Pathway antibodies  P38 MAPK Signaling Pathway Diagram

Diseases associated with anti-MAP3K10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with MAP3K10 and Inflammation
 Necrosis Antibodies  >2 publications with MAP3K10 and Necrosis
 Mental Disorders Antibodies  >1 publications with MAP3K10 and Mental Disorders
 Liver Neoplasms Antibodies  >1 publications with MAP3K10 and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with MAP3K10 and Cardiovascular Diseases

Organs/Tissues associated with anti-MAP3K10 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with MAP3K10 and Lung
 Brain Antibodies  >4 publications with MAP3K10 and Brain
 Testis Antibodies  >3 publications with MAP3K10 and Testis
 Kidney Antibodies  >2 publications with MAP3K10 and Kidney
 Stomach Antibodies  >2 publications with MAP3K10 and Stomach
 Embryonic Tissue Antibodies  >2 publications with MAP3K10 and Embryonic Tissue
 Bone Antibodies  >2 publications with MAP3K10 and Bone
 Blood Antibodies  >1 publications with MAP3K10 and Blood
 Liver Antibodies  >1 publications with MAP3K10 and Liver
 Spleen Antibodies  >1 publications with MAP3K10 and Spleen
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