DCN ELISA Kit for Rat

Name: Rat DCN ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS2501519
Price: 300 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2501519

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of DCN in Rat serum, plasma and other biological fluidsPrinciple of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this… More details

$300 / 24 Tests (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

DCN, ELISA Kit

Full Product Name

Rat DCN (Decorin) ELISA Kit

Product Gene Name

DCN elisa kit

Species Reactivity

Rat

Assay Type

Sandwich

Samples

Serum, Plasma, Biological Fluids

Detection Range

7.813-500pg/mL

Sensitivity

Min: 4.688pg/mL; Max: 500pg/mL

Specificity

This assay has high sensitivity and excellent specificity for detection of Rat DCN. No significant cross-reactivity or interference between Rat DCN and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Rat DCN and all the analogues, therefore, cross reaction may still exist.

Preparation and Storage

Store at 4 degree C.

Molecular Weight

8,266 Da

OMIM

125255

3D Structure

ModBase 3D Structure for P07585

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DCN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCN purchase

MBS2501519 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the DCN, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DCN. The ELISA analytical biochemical technique of the MBS2501519 kit is based on DCN antibody-DCN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DCN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DCN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for DCN. It may not necessarily be applicable to this product.

NCBI GI #

19743854

NCBI GeneID

1634

NCBI Accession #

NP_598014.1

UniProt Primary Accession #

P07585

UniProt Secondary Accession #

Q9P0Z0; Q9P0Z1; Q9Y5N8; Q9Y5N9

UniProt Related Accession #

P07585

GenBank Nucleotide #

NM_133507.2

NCBI Official Full Name

decorin isoform e

NCBI Official Synonym Full Names

decorin

NCBI Official Symbol

DCN

NCBI Official Synonym Symbols

CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B

UniProt Protein Name

Decorin

UniProt Synonym Protein Names

Bone proteoglycan II; PG-S2; PG40

Protein Family

Decorin

UniProt Gene Name

DCN

UniProt Synonym Gene Names

SLRR1B

UniProt Entry Name

PGS2_HUMAN

NCBI Protein Information

decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; dermatan sulphate proteoglycans II; proteoglycan core protein; small leucine-rich protein 1B

NCBI Summary for DCN

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for DCN

DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; extracellular space; Golgi lumen; extracellular region; collagen type VI

Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding

Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; wound healing; glycosaminoglycan metabolic process; pathogenesis; response to lipopolysaccharide; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; carbohydrate metabolic process; chondroitin sulfate catabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; aging; placenta development

Disease: Corneal Dystrophy, Congenital Stromal

Research Articles on DCN

1. Lumican, decorin and dermatopontin are differentially expressed and may serve as biomarkers for metastatic and recurrent Giant cell tumor of bone

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DCN elisa kit

Reference Product	PubMed Publications
TGFB1 elisa kit	>85 publications with DCN and TGFB1
VCAN elisa kit	>71 publications with DCN and VCAN
EGFR elisa kit	>21 publications with DCN and EGFR
COL1A2 elisa kit	>7 publications with DCN and COL1A2
THBS1 elisa kit	>6 publications with DCN and THBS1
FN1 elisa kit	>5 publications with DCN and FN1
DPT elisa kit	>4 publications with DCN and DPT
FBN1 elisa kit	>4 publications with DCN and FBN1
ELN elisa kit	>1 publications with DCN and ELN

Pathways associated with DCN elisa kit

Products by Pathway	Pathway Diagram
A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies	A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
CS/DS Degradation Pathway antibodies	CS/DS Degradation Pathway Diagram
Chondroitin Sulfate Biosynthesis Pathway antibodies	Chondroitin Sulfate Biosynthesis Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Defective B3GAT3 Causes JDSSDHD Pathway antibodies	Defective B3GAT3 Causes JDSSDHD Pathway Diagram
Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies	Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies	Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies	Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
Defective CHST3 Causes SEDCJD Pathway antibodies	Defective CHST3 Causes SEDCJD Pathway Diagram
Defective CHST6 Causes MCDC1 Pathway antibodies	Defective CHST6 Causes MCDC1 Pathway Diagram

Diseases associated with DCN elisa kit

Disease Name	Pubmed Publications
Fibrosis Antibodies	>124 publications with DCN and Fibrosis
Disease Models, Animal Antibodies	>99 publications with DCN and Disease Models, Animal
Carcinoma Antibodies	>75 publications with DCN and Carcinoma
Inflammation Antibodies	>57 publications with DCN and Inflammation
Kidney Diseases Antibodies	>46 publications with DCN and Kidney Diseases
Adenocarcinoma Antibodies	>28 publications with DCN and Adenocarcinoma
Neoplasms, Experimental Antibodies	>25 publications with DCN and Neoplasms, Experimental
Necrosis Antibodies	>24 publications with DCN and Necrosis
Liver Diseases Antibodies	>23 publications with DCN and Liver Diseases
Breast Neoplasms Antibodies	>22 publications with DCN and Breast Neoplasms

Organs/Tissues associated with DCN elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>700 publications with DCN and Brain
Nerve Antibodies	>302 publications with DCN and Nerve
Connective Tissue Antibodies	>169 publications with DCN and Connective Tissue
Skin Antibodies	>163 publications with DCN and Skin
Bone Antibodies	>155 publications with DCN and Bone
Muscle Antibodies	>155 publications with DCN and Muscle
Vascular Antibodies	>135 publications with DCN and Vascular
Ear Antibodies	>90 publications with DCN and Ear
Kidney Antibodies	>82 publications with DCN and Kidney
Embryonic Tissue Antibodies	>67 publications with DCN and Embryonic Tissue