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PPAP2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7004500

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P.… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PPAP2B, Polyclonal Antibody
Full Product Name
PPAP2B Antibody; Biotin conjugated
Product Gene Name
anti-PPAP2B antibody
Product Synonym Names
Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP; PPAP2B; LPP3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%,Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
Matching Pairs
Unconjugated Antibody: PPAP2B (MBS7002383)
Biotin Conjugated Antibody: PPAP2B (MBS7004500)
Molecular Weight
35,116 Da
OMIM
607125
3D Structure
ModBase 3D Structure for O14495
Immunogen
Recombinant human Lipid phosphate phosphohydrolase 3 protein
Conjugation
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PPAP2B antibody
ELISA (EIA)

Other Notes

Small volumes of anti-PPAP2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPAP2B purchase

MBS7004500 is an antibody targeting PPAP2B. Also known as PPAP2B Antibody; Biotin conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPAP2B. It may not necessarily be applicable to this product.

NCBI GI #
29171740
NCBI GeneID
8613
NCBI Accession #
NP_003704.3
UniProt Primary Accession #
O14495
UniProt Secondary Accession #
Q5U0F7; Q96GW0; Q99782; B2R651; D3DQ52
UniProt Related Accession #
O14495
GenBank Nucleotide #
NM_003713.4
NCBI Official Full Name
phospholipid phosphatase 3
NCBI Official Synonym Full Names
phospholipid phosphatase 3
NCBI Official Symbol
PLPP3
NCBI Official Synonym Symbols
LPP3; VCIP; Dri42; PAP2B; PPAP2B
UniProt Protein Name
Phospholipid phosphatase 3
UniProt Synonym Protein Names
Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP
UniProt Gene Name
PLPP3
UniProt Synonym Gene Names
PAP-2b; PAP2b; VCIP
UniProt Entry Name
PLPP3_HUMAN
NCBI Protein Information
phospholipid phosphatase 3

NCBI Summary for PPAP2B

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
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UniProt Comments for PPAP2B

PPAP2B: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. Belongs to the PA-phosphatase related phosphoesterase family.

Protein type: Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Phosphatase, lipid; Lipid Metabolism - sphingolipid; EC 3.1.3.4; Lipid Metabolism - glycerolipid; Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p32.2

Cellular Component: adherens junction; endoplasmic reticulum membrane; Golgi apparatus; integral to plasma membrane; membrane; plasma membrane

Molecular Function: integrin binding; lipid phosphatase activity; phosphatidate phosphatase activity; phosphoprotein phosphatase activity; protein binding; sphingosine-1-phosphate phosphatase activity

Biological Process: Bergmann glial cell differentiation; blood vessel development; gastrulation with mouth forming second; germ cell migration; homotypic cell-cell adhesion; lipid metabolic process; negative regulation of protein amino acid phosphorylation; phospholipid dephosphorylation; phospholipid metabolic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription factor activity; protein amino acid dephosphorylation; protein stabilization; regulation of Wnt receptor signaling pathway; sphingolipid biosynthetic process; sphingolipid metabolic process
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Research Articles on PPAP2B

1. Mechanosensitive PPAP2B plays a critical role in promoting anti-inflammatory phenotype and maintaining vascular integrity of endothelial monolayer under atheroprotective flow.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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