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PRMT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624622

Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential… More details

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Product Overview

Online Datasheet in PDF
Product Name
PRMT1, Polyclonal Antibody
Full Product Name
PRMT1, CT (Protein Arginine N-Methyltransferase 1, Interferon Receptor 1-bound Protein 4, HMT2, HRMT1L2, IR1B4)
Product Gene Name
anti-PRMT1 antibody
Product Synonym Names
Anti -PRMT1, CT (Protein Arginine N-Methyltransferase 1, Interferon Receptor 1-bound Protein 4, HMT2, HRMT1L2, IR1B4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PRMT1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,557 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (50180496..50191704). Location: 19q13.3
3D Structure
ModBase 3D Structure for Q5U8W9
Immunogen
Synthetic peptide selected from the C-terminal region of human PRMT1 (KLH).

Product Categories/Family for anti-PRMT1 antibody

Antibodies; Abs to Enzymes; Methyltransferase
Applications Tested/Suitable for anti-PRMT1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PRMT1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-PRMT1 antibody

Western blot analysis of PRMT1 (arrow) using rabbit polyclonal PRMT1 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRMT1 gene (Lane 2).
Rabbit Anti-PRMT1 Polyclonal Antibody – Cat# MBS624622

Immunohistochemistry (IHC) of anti-PRMT1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-PRMT1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624622

Other Notes

Small volumes of anti-PRMT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRMT1 purchase

MBS624622 is an antibody targeting PRMT1. Also known as PRMT1, CT (Protein Arginine N-Methyltransferase 1, Interferon Receptor 1-bound Protein 4, HMT2, HRMT1L2, IR1B4). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRMT1. It may not necessarily be applicable to this product.

NCBI GI #
333360913
NCBI GeneID
3276
NCBI Accession #
NP_001193971.1
UniProt Primary Accession #
Q5U8W9
UniProt Related Accession #
Q5U8W9; Q8WUW5; Q99873
GenBank Nucleotide #
NM_001207042.1
NCBI Official Full Name
protein arginine N-methyltransferase 1 isoform 4
NCBI Official Synonym Full Names
protein arginine methyltransferase 1
NCBI Official Symbol
PRMT1
NCBI Official Synonym Symbols
ANM1; HCP1; IR1B4; HRMT1L2
UniProt Protein Name
Protein arginine methyltransferase 1 isoform 4
Protein Family
Probable protein arginine N-methyltransferase
UniProt Gene Name
HRMT1L2
UniProt Entry Name
Q5U8W9_HUMAN
NCBI Protein Information
protein arginine N-methyltransferase 1; OTTHUMP00000236172; OTTHUMP00000236176; OTTHUMP00000236178; OTTHUMP00000236179; HMT1 hnRNP methyltransferase-like 2; interferon receptor 1-bound protein 4; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2

NCBI Summary for PRMT1

The PRMT1 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for H4 (see MIM 602822).[supplied by OMIM]

UniProt Comments for PRMT1

PRMT1: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP. Widely expressed. By BTG1, BTG2 and ILF3. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; Methyltransferase, protein arginine; EC 2.1.1.125; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; histone methyltransferase activity; identical protein binding; protein binding; N-methyltransferase activity

Biological Process: histone methylation; peptidyl-arginine methylation; establishment and/or maintenance of chromatin architecture; cell surface receptor linked signal transduction; protein amino acid methylation; regulation of transcription, DNA-dependent; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; neurite development; negative regulation of megakaryocyte differentiation
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Research Articles on PRMT1

1. methylation of Axin by PRMT1 may serve as a finely tuned regulation mechanism for Wnt/beta-catenin signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRMT1 antibody

 Reference Product  PubMed Publications
 BTG2 antibody  >8 publications with PRMT1 and BTG2
 STAT1 antibody  >7 publications with PRMT1 and STAT1
 PRMT8 antibody  >7 publications with PRMT1 and PRMT8
 BTG1 antibody  >7 publications with PRMT1 and BTG1
 KHDRBS1 antibody  >5 publications with PRMT1 and KHDRBS1
 ILF3 antibody  >4 publications with PRMT1 and ILF3
 FUS antibody  >2 publications with PRMT1 and FUS
 NCOA3 antibody  >2 publications with PRMT1 and NCOA3
 NCOA2 antibody  >2 publications with PRMT1 and NCOA2
 NCOA1 antibody  >2 publications with PRMT1 and NCOA1

Pathways associated with anti-PRMT1 antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-PRMT1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with PRMT1 and Neoplasms
 Disease Models, Animal Antibodies  >9 publications with PRMT1 and Disease Models, Animal
 Hepatitis Antibodies  >8 publications with PRMT1 and Hepatitis
 Breast Neoplasms Antibodies  >8 publications with PRMT1 and Breast Neoplasms
 Skin Diseases Antibodies  >8 publications with PRMT1 and Skin Diseases
 Heart Diseases Antibodies  >7 publications with PRMT1 and Heart Diseases
 Kidney Diseases Antibodies  >6 publications with PRMT1 and Kidney Diseases
 Lung Diseases Antibodies  >6 publications with PRMT1 and Lung Diseases
 Nervous System Diseases Antibodies  >5 publications with PRMT1 and Nervous System Diseases
 Necrosis Antibodies  >5 publications with PRMT1 and Necrosis

Organs/Tissues associated with anti-PRMT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with PRMT1 and Blood
 Kidney Antibodies  >12 publications with PRMT1 and Kidney
 Liver Antibodies  >12 publications with PRMT1 and Liver
 Brain Antibodies  >11 publications with PRMT1 and Brain
 Muscle Antibodies  >9 publications with PRMT1 and Muscle
 Heart Antibodies  >9 publications with PRMT1 and Heart
 Vascular Antibodies  >8 publications with PRMT1 and Vascular
 Intestine Antibodies  >6 publications with PRMT1 and Intestine
 Lung Antibodies  >6 publications with PRMT1 and Lung
 Thyroid Antibodies  >4 publications with PRMT1 and Thyroid
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