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RelB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6392333

RelB is a component of the NF-kappaB complex of transcription factors. These factors are a critical regulator in the differentiation of dendritic cells and are key regulators of immune, inflammatory and acute phase responses and are also implicated in the… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RelB, Polyclonal Antibody
Full Product Name
RelB (v-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Transcription Factor RelB, REL-B, IREL, I-Rel) (Biotin)
Product Gene Name
anti-RelB antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human RELB.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
62,134 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (45504707..45541456). Location: 19q13.32
OMIM
604758
3D Structure
ModBase 3D Structure for Q01201
Immunogen
Full length human RELB, aa1-579 (NP_006500.2).
Immunogen Sequence
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVFSRASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGVDKKRKRGMPDVLGELNSSDPHGIESKRRKKKPAILDHFLPNHGSGPFLPPSALLPDPDFFSGTVSLPGLEPPGGPDLLDDGFAYDPTAPTLFTMLDLLPPAPPHASAVVCSGGAGAVVGETPGPEPLTLDSYQAPGPGDGGTASLVGSNMFPNHYREAAFGGGLLSPGPEAT
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-RelB antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-RelB antibody
Western Blot (WB)
Application Notes for anti-RelB antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-RelB antibody

Western Blot analysis of RELB expression in transfected 293T cell line by RELB polyclonal antibody. Lane 1: RELB transfected lysate (62.1kD). Lane 2: Non-transfected lysate.
Rabbit Anti-RelB Polyclonal Antibody – Cat# MBS6392333

Testing Data of anti-RelB antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between RELB and RELA HeLa cells were stained with RELB rabbit purified polyclonal 1:1200 and RELA mouse monoclonal antibody 1:50. Signals were detected by 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.
Rabbit Anti-RelB Polyclonal Antibody, Testing Data – Cat# MBS6392333

Other Notes

Small volumes of anti-RelB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RelB purchase

MBS6392333 is an antibody targeting RelB. Also known as RelB (v-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Transcription Factor RelB, REL-B, IREL, I-Rel) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RelB. It may not necessarily be applicable to this product.

NCBI GI #
35493878
NCBI GeneID
5971
NCBI Accession #
NP_006500.2
UniProt Primary Accession #
Q01201
UniProt Secondary Accession #
Q6GTX7; Q9UEI7
UniProt Related Accession #
Q01201
GenBank Nucleotide #
NM_006509.2
NCBI Official Full Name
transcription factor RelB
NCBI Official Synonym Full Names
v-rel reticuloendotheliosis viral oncogene homolog B
NCBI Official Symbol
RELB
NCBI Official Synonym Symbols
IREL; I-REL; REL-B
UniProt Protein Name
Transcription factor RelB
UniProt Synonym Protein Names
I-Rel
Protein Family
Antitoxin
UniProt Gene Name
RELB
UniProt Entry Name
RELB_HUMAN
NCBI Protein Information
transcription factor RelB; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide ge

UniProt Comments for RelB

RELB: a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center; cytosol

Molecular Function: protein binding; chromatin binding; transcription corepressor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; antigen processing and presentation; I-kappaB kinase/NF-kappaB cascade; response to cytokine stimulus; T-helper 1 cell differentiation; innate immune response; myeloid dendritic cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; inflammatory response
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Research Articles on RelB

1. Kaposi's sarcoma-associated herpesvirus oncoprotein K13 upregulated the expression of NF-kappaB subunit RelB and blocked the anti-IgM-induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RelB antibody

 Reference Product  PubMed Publications
 RELA antibody  >261 publications with RelB and RELA
 NFKB2 antibody  >88 publications with RelB and NFKB2
 NFKB1 antibody  >28 publications with RelB and NFKB1
 SMARCA4 antibody  >2 publications with RelB and SMARCA4
 DPF2 antibody  >2 publications with RelB and DPF2
 HDAC6 antibody  >1 publications with RelB and HDAC6

Pathways associated with anti-RelB antibody

 Products by Pathway  Pathway Diagram
 Alternative NF-kappaB Pathway antibodies  Alternative NF-kappaB Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram

Diseases associated with anti-RelB antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >186 publications with RelB and Necrosis
 Neoplasms Antibodies  >157 publications with RelB and Neoplasms
 Inflammation Antibodies  >124 publications with RelB and Inflammation
 Breast Neoplasms Antibodies  >28 publications with RelB and Breast Neoplasms
 Nervous System Diseases Antibodies  >20 publications with RelB and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >18 publications with RelB and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >15 publications with RelB and Prostatic Neoplasms
 Lung Diseases Antibodies  >15 publications with RelB and Lung Diseases
 Liver Diseases Antibodies  >14 publications with RelB and Liver Diseases
 Kidney Diseases Antibodies  >12 publications with RelB and Kidney Diseases

Organs/Tissues associated with anti-RelB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >269 publications with RelB and Blood
 Bone Marrow Antibodies  >63 publications with RelB and Bone Marrow
 Spleen Antibodies  >50 publications with RelB and Spleen
 Thymus Antibodies  >38 publications with RelB and Thymus
 Vascular Antibodies  >32 publications with RelB and Vascular
 Lung Antibodies  >31 publications with RelB and Lung
 Lymph Node Antibodies  >30 publications with RelB and Lymph Node
 Lymph Antibodies  >29 publications with RelB and Lymph
 Kidney Antibodies  >27 publications with RelB and Kidney
 Muscle Antibodies  >26 publications with RelB and Muscle
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