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RGS7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6341799

RGS7 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RGS7, Polyclonal Antibody
Full Product Name
RGS7, CT (RGS7, Regulator of G-protein signaling 7) (FITC)
Product Gene Name
anti-RGS7 antibody
Product Synonym Names
RGS7; Regulator of G-protein signaling 7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
57,668 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (240938817..241520478, complement). Location: 1q43; 1q23.1
OMIM
602517
3D Structure
ModBase 3D Structure for P49802
Immunogen
RGS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 447-477 amino acids from the C-terminal region of human RGS7.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-RGS7 antibody

Antibodies; G Proteins
Applications Tested/Suitable for anti-RGS7 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-RGS7 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-RGS7 antibody

RGS7 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the RGS7 antibody detected the RGS7 protein (arrow).
Rabbit Anti-RGS7 Polyclonal Antibody – Cat# MBS6341799

Immunohistochemistry (IHC) of anti-RGS7 antibody

RGS7 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RGS7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-RGS7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6341799

Product References and Citations for anti-RGS7 antibody

Bailey, S.D., et al. Diabetes Care (2010). In press: Wang, J., et al. Carcinogenesis (2010). In press: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). McCauley, J.L., et al. Genes Immun. 10(7):624-630(2009).

Other Notes

Small volumes of anti-RGS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGS7 purchase

MBS6341799 is an antibody targeting RGS7. Also known as RGS7, CT (RGS7, Regulator of G-protein signaling 7) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RGS7. It may not necessarily be applicable to this product.

NCBI GI #
156627563
NCBI GeneID
6000
NCBI Accession #
NP_002915.3
UniProt Primary Accession #
P49802
UniProt Secondary Accession #
Q5T3H4; Q8TD66; Q8TD67; Q8WW09; Q9UNU7; Q9Y6B9
UniProt Related Accession #
P49802
GenBank Nucleotide #
NM_002924.4
NCBI Official Full Name
regulator of G-protein signaling 7
NCBI Official Synonym Full Names
regulator of G-protein signaling 7
NCBI Official Symbol
RGS7
UniProt Protein Name
Regulator of G-protein signaling 7
Protein Family
Regulator of G-protein signaling
UniProt Gene Name
RGS7
UniProt Synonym Gene Names
RGS7
UniProt Entry Name
RGS7_HUMAN
NCBI Protein Information
regulator of G-protein signaling 7; regulator of G-protein signalling 7; regulator of G-protein signaling RGS7

UniProt Comments for RGS7

RGS7: inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP. Four alternatively spliced isoforms have been described.

Protein type: GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 1q43|1q23.1

Cellular Component: cytoplasm; plasma membrane; heterotrimeric G-protein complex; nucleus; cytosol

Molecular Function: signal transducer activity; G-protein beta-subunit binding; GTPase activator activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
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Research Articles on RGS7

1. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RGS7 antibody

 Reference Product  PubMed Publications
 GNB5 antibody  >30 publications with RGS7 and GNB5
 SNAPIN antibody  >1 publications with RGS7 and SNAPIN
 PRKCA antibody  >1 publications with RGS7 and PRKCA
 PKD1 antibody  >1 publications with RGS7 and PKD1

Pathways associated with anti-RGS7 antibody

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-RGS7 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with RGS7 and Nervous System Diseases
 Kidney Diseases Antibodies  >6 publications with RGS7 and Kidney Diseases
 Necrosis Antibodies  >4 publications with RGS7 and Necrosis
 Seizures Antibodies  >3 publications with RGS7 and Seizures
 Neoplasms Antibodies  >3 publications with RGS7 and Neoplasms
 Abnormalities, Multiple Antibodies  >1 publications with RGS7 and Abnormalities, Multiple
 Intestinal Neoplasms Antibodies  >1 publications with RGS7 and Intestinal Neoplasms
 Memory Disorders Antibodies  >1 publications with RGS7 and Memory Disorders
 Weight Loss Antibodies  >1 publications with RGS7 and Weight Loss
 Pulmonary Embolism Antibodies  >1 publications with RGS7 and Pulmonary Embolism

Organs/Tissues associated with anti-RGS7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >53 publications with RGS7 and Brain
 Eye Antibodies  >19 publications with RGS7 and Eye
 Nerve Antibodies  >6 publications with RGS7 and Nerve
 Connective Tissue Antibodies  >3 publications with RGS7 and Connective Tissue
 Lung Antibodies  >2 publications with RGS7 and Lung
 Embryonic Tissue Antibodies  >2 publications with RGS7 and Embryonic Tissue
 Pituitary Gland Antibodies  >1 publications with RGS7 and Pituitary Gland
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