SCRIB Antibody – Rabbit Polyclonal

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Scribble: may be involved in regulating neuroblast cortical polarity, cell size asymmetry and mitotic spindle asymmetry. A neoplastic tumor suppressor genes in Drosophila melanogaster. May play a role in the suppression of mammalian tumorigenesis. Gene ablation in the mouse causes severe neural tube defects. May be implicated in the etiology of human NTDs. Involved in the regulation of synaptic plasticity and synaptic vesicle dynamics. May be required to sustain synaptic vesicle concentrations at their sites of release. Targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein.

Protein type: Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: nucleoplasm; presynaptic membrane; postsynaptic membrane; cell-cell adherens junction; lamellipodium; basolateral plasma membrane; leading edge; plasma membrane; intercellular junction

Molecular Function: protein binding

Biological Process: cell migration; viral reproduction; wound healing; positive regulation of apoptosis; establishment of apical/basal cell polarity; cochlear nucleus development; asymmetric protein localization; cell proliferation; cell-cell adhesion; positive chemotaxis; neural tube closure; synaptic vesicle endocytosis; negative regulation of mitotic cell cycle; auditory receptor cell stereocilium organization and biogenesis; synaptic vesicle targeting; positive regulation of receptor recycling; astrocyte cell migration