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SH3GLB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9412588

This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SH3GLB1, Polyclonal Antibody
Full Product Name
SH3GLB1 Antibody
Product Gene Name
anti-SH3GLB1 antibody
Product Synonym Names
Bif-1; CGI-61; PPP1R70; dJ612B15.2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purity/Purification
Antigen affinity purification.
Concentration
1.3 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total SH3GLB1 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
29,318 Da
OMIM
609287
3D Structure
ModBase 3D Structure for Q9Y371
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to a region derived from internal residues of human SH3-domain GRB2-like endophilin B
Target Name
SH3GLB1

Product Categories/Family for anti-SH3GLB1 antibody

Total protein Ab
Applications Tested/Suitable for anti-SH3GLB1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-SH3GLB1 antibody
Immunohistochemistry: 1:15-1:50

Immunohistochemistry (IHC) of anti-SH3GLB1 antibody

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/30.
Rabbit Anti-SH3GLB1 Polyclonal Antibody – Cat# MBS9412588

Immunohistochemistry (IHC) of anti-SH3GLB1 antibody

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.
Rabbit Anti-SH3GLB1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9412588

Other Notes

Small volumes of anti-SH3GLB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SH3GLB1 purchase

MBS9412588 is an antibody targeting SH3GLB1. Also known as SH3GLB1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SH3GLB1. It may not necessarily be applicable to this product.

NCBI GI #
331284170
NCBI GeneID
51100
NCBI Accession #
NP_001193580.1
UniProt Primary Accession #
Q9Y371
UniProt Secondary Accession #
Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; B4E182
UniProt Related Accession #
Q9Y371
GenBank Nucleotide #
NM_001206651.1
NCBI Official Full Name
endophilin-B1 isoform 2
NCBI Official Synonym Full Names
SH3-domain GRB2-like endophilin B1
NCBI Official Symbol
SH3GLB1
NCBI Official Synonym Symbols
Bif-1; CGI-61; PPP1R70; dJ612B15.2
UniProt Protein Name
Endophilin-B1
UniProt Synonym Protein Names
Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1
Protein Family
Endophilin
UniProt Gene Name
SH3GLB1
UniProt Synonym Gene Names
KIAA0491; Bif-1
UniProt Entry Name
SHLB1_HUMAN
NCBI Protein Information
endophilin-B1

UniProt Comments for SH3GLB1

SH3GLB1: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Mitochondrial; EC 2.3.1.-; Apoptosis; Transferase

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: Golgi membrane; mitochondrial outer membrane; cytoplasm

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; lipid binding

Biological Process: positive regulation of protein oligomerization; apoptosis; protein oligomerization
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Research Articles on SH3GLB1

1. Our findings suggest that endophilin-B1 is a key mediator of a feed-forward mechanism of Alzheimer's disease pathogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SH3GLB1 antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram

Diseases associated with anti-SH3GLB1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with SH3GLB1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >3 publications with SH3GLB1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >3 publications with SH3GLB1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >2 publications with SH3GLB1 and Nervous System Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with SH3GLB1 and Urinary Bladder Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with SH3GLB1 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >1 publications with SH3GLB1 and Fibrosis
 Hyperplasia Antibodies  >1 publications with SH3GLB1 and Hyperplasia
 Inflammation Antibodies  >1 publications with SH3GLB1 and Inflammation
 Lung Neoplasms Antibodies  >1 publications with SH3GLB1 and Lung Neoplasms

Organs/Tissues associated with anti-SH3GLB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with SH3GLB1 and Blood
 Brain Antibodies  >3 publications with SH3GLB1 and Brain
 Stomach Antibodies  >2 publications with SH3GLB1 and Stomach
 Prostate Antibodies  >2 publications with SH3GLB1 and Prostate
 Muscle Antibodies  >2 publications with SH3GLB1 and Muscle
 Pancreas Antibodies  >2 publications with SH3GLB1 and Pancreas
 Lung Antibodies  >2 publications with SH3GLB1 and Lung
 Lymph Antibodies  >1 publications with SH3GLB1 and Lymph
 Kidney Antibodies  >1 publications with SH3GLB1 and Kidney
 Liver Antibodies  >1 publications with SH3GLB1 and Liver
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