SLCO1B3 Antibody – Rabbit Polyclonal

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]

SLCO1B3: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B3 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 12p12.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: bile acid transmembrane transporter activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; bile acid metabolic process; organic anion transport; sodium-independent organic anion transport

Disease: Hyperbilirubinemia, Rotor Type