Rabbit Anti-TRIM33 Polyclonal Antibody – Cat# MBS6358293

Western Blot analysis of MBS644763 in MDA-MB435 cell line lysates (35ug/lane). This demonstrates that MBS644763 detected the TRIM33 protein (arrow).

TRIM33 Antibody – Rabbit Polyclonal

Name: TRIM33 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6358293
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6358293

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRIM33, Polyclonal Antibody

Full Product Name

TRIM33, CT (TRIM33, KIAA1113, RFG7, TIF1G, E3 ubiquitin-protein ligase TRIM33, Ectodermin homolog, RET-fused gene 7 protein, Transcription intermediary factor 1-gamma, Tripartite motif-containing protein 33) (MaxLight 550)

Product Gene Name

anti-TRIM33 antibody

Product Synonym Names

TRIM33; KIAA1113; RFG7; TIF1G; E3 ubiquitin-protein ligase TRIM33; Ectodermin homolog; RET-fused gene 7 protein; Transcription intermediary factor 1-gamma; Tripartite motif-containing protein 33

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein A and Peptide Affinity Chromatography.

Specificity

Recognizes human TRIM33.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

120,541 Da

OMIM

188550

3D Structure

ModBase 3D Structure for Q9UPN9

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1095-1125 in the C-terminal region of human TRIM33, UniProt Accession #Q9UPN9. Species sequence homology: mouse

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-TRIM33 antibody

Antibodies; Transcription Factors; TRIM (Tripartite Motif)

Applications Tested/Suitable for anti-TRIM33 antibody

Western Blot (WB), FLISA

Application Notes for anti-TRIM33 antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-TRIM33 antibody

1. Bai, X., et al. Cell 142(1):133-143(2010). 2. Howard, P.W., et al. Biochem. Biophys. Res. Commun. 396(3):674-678(2010). 3. Vincent, D.F., et al. PLoS Genet. 5 (7), E1000575 (2009). 4. Dupont, S., et al. Cell 136(1):123-135(2009). 5. Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007).

Other Notes

Small volumes of anti-TRIM33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIM33 purchase

MBS6358293 is an antibody targeting TRIM33. Also known as TRIM33, CT (TRIM33, KIAA1113, RFG7, TIF1G, E3 ubiquitin-protein ligase TRIM33, Ectodermin homolog, RET-fused gene 7 protein, Transcription intermediary factor 1-gamma, Tripartite motif-containing protein 33) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM33. It may not necessarily be applicable to this product.

NCBI GI #

74027251

NCBI GeneID

51592

NCBI Accession #

NP_148980.2

NCBI Related Accession #

NP_056990.3

UniProt Primary Accession #

Q9UPN9

UniProt Secondary Accession #

O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79

UniProt Related Accession #

Q9UPN9

GenBank Nucleotide #

NM_033020.2

NCBI Official Full Name

E3 ubiquitin-protein ligase TRIM33 isoform beta

NCBI Official Synonym Full Names

tripartite motif containing 33

NCBI Official Symbol

TRIM33

NCBI Official Synonym Symbols

ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA

UniProt Protein Name

E3 ubiquitin-protein ligase TRIM33

UniProt Synonym Protein Names

Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

TRIM33

UniProt Synonym Gene Names

KIAA1113; RFG7; TIF1G; Protein Rfg7; TIF1-gamma

UniProt Entry Name

TRI33_HUMAN

NCBI Protein Information

E3 ubiquitin-protein ligase TRIM33

UniProt Comments for TRIM33

TIF1G: an atypical protein kinase that functions as a transcriptional repressor. Translocation with RET generates the TRIM33/RET (PTC7) oncogene. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Two splice variant isoforms have been described.

Protein type: Ubiquitin ligase; Transcription, coactivator/corepressor; EC 6.3.2.19; Protein kinase, atypical; Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Kinase, protein; ATYPICAL group; TIF1 family

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; protein ubiquitination; gene expression; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of BMP signaling pathway

Disease: Thyroid Carcinoma, Papillary

Research Articles on TRIM33

1. our work indicates that TIF1gamma exerts its tumor-suppressive functions in part by promoting chromosomal stability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRIM33 antibody

Reference Product	PubMed Publications
SMAD4 antibody	>28 publications with TRIM33 and SMAD4
SMAD2 antibody	>9 publications with TRIM33 and SMAD2
TRIM24 antibody	>4 publications with TRIM33 and TRIM24
SMAD3 antibody	>4 publications with TRIM33 and SMAD3
LDB1 antibody	>1 publications with TRIM33 and LDB1

Pathways associated with anti-TRIM33 antibody

Products by Pathway	Pathway Diagram
Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies	Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By TGF-beta Receptor Complex Pathway antibodies	Signaling By TGF-beta Receptor Complex Pathway Diagram
Transcriptional Activity Of SMAD2/SMAD3:SMAD4 Heterotrimer Pathway antibodies	Transcriptional Activity Of SMAD2/SMAD3:SMAD4 Heterotrimer Pathway Diagram

Diseases associated with anti-TRIM33 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>11 publications with TRIM33 and Adenocarcinoma
Cell Transformation, Neoplastic Antibodies	>5 publications with TRIM33 and Cell Transformation, Neoplastic
Liver Neoplasms Antibodies	>4 publications with TRIM33 and Liver Neoplasms
Neoplasm Metastasis Antibodies	>4 publications with TRIM33 and Neoplasm Metastasis
Liver Diseases Antibodies	>4 publications with TRIM33 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>4 publications with TRIM33 and Carcinoma, Hepatocellular
Fibrosis Antibodies	>2 publications with TRIM33 and Fibrosis
Neoplasms, Experimental Antibodies	>2 publications with TRIM33 and Neoplasms, Experimental
Inflammation Antibodies	>2 publications with TRIM33 and Inflammation
Kidney Diseases Antibodies	>2 publications with TRIM33 and Kidney Diseases

Organs/Tissues associated with anti-TRIM33 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>20 publications with TRIM33 and Blood
Lung Antibodies	>8 publications with TRIM33 and Lung
Bone Antibodies	>7 publications with TRIM33 and Bone
Liver Antibodies	>6 publications with TRIM33 and Liver
Embryonic Tissue Antibodies	>5 publications with TRIM33 and Embryonic Tissue
Bone Marrow Antibodies	>4 publications with TRIM33 and Bone Marrow
Brain Antibodies	>4 publications with TRIM33 and Brain
Connective Tissue Antibodies	>3 publications with TRIM33 and Connective Tissue
Mammary Gland Antibodies	>3 publications with TRIM33 and Mammary Gland
Skin Antibodies	>3 publications with TRIM33 and Skin