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AK5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6006067

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

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Product Overview

Online Datasheet in PDF
Product Name
AK5, Polyclonal Antibody
Full Product Name
AK5, NT (Adenylate Kinase Isoenzyme 5, AK 5, ATP-AMP Transphosphorylase 5)
Product Gene Name
anti-AK5 antibody
Product Synonym Names
Anti -AK5, NT (Adenylate Kinase Isoenzyme 5, AK 5, ATP-AMP Transphosphorylase 5)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human AK5. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
63,333 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (77747662..78025654). Location: 1p31
OMIM
608009
3D Structure
ModBase 3D Structure for Q9Y6K8
Immunogen
Synthetic peptide selected from the N-terminal region of human AK5 (KLH).

Product Categories/Family for anti-AK5 antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-AK5 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AK5 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-AK5 antibody

The anti-AK5 Pab is used in Western blot to detect AK5 in mouse liver tissue lysate.
Rabbit Anti-AK5 Polyclonal Antibody – Cat# MBS6006067

Immunohistochemistry (IHC) of anti-AK5 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-AK5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6006067

Immunohistochemistry (IHC) of anti-AK5 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with AK5 Antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-AK5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6006067

Other Notes

Small volumes of anti-AK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AK5 purchase

MBS6006067 is an antibody targeting AK5. Also known as AK5, NT (Adenylate Kinase Isoenzyme 5, AK 5, ATP-AMP Transphosphorylase 5). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AK5. It may not necessarily be applicable to this product.

NCBI GI #
49456735
NCBI GeneID
26289
NCBI Accession #
CAG46688.1
UniProt Primary Accession #
Q9Y6K8
UniProt Secondary Accession #
Q5U622; Q6FH66; Q7Z4T5; Q86YS0; Q8N464; Q96EC9
UniProt Related Accession #
Q9Y6K8
NCBI Official Full Name
AK5
NCBI Official Synonym Full Names
adenylate kinase 5
NCBI Official Symbol
AK5
NCBI Official Synonym Symbols
AK6
UniProt Protein Name
Adenylate kinase isoenzyme 5
UniProt Synonym Protein Names
ATP-AMP transphosphorylase 5
Protein Family
Adenylate kinase
UniProt Gene Name
AK5
UniProt Synonym Gene Names
AK 5
UniProt Entry Name
KAD5_HUMAN
NCBI Protein Information
adenylate kinase isoenzyme 5; AK 5; adenylate kinase 6; ATP-AMP transphosphorylase 5

NCBI Summary for AK5

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for AK5

AK5: Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Belongs to the adenylate kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, other; EC 2.7.4.3; EC 2.7.4.6; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: cytoplasm; microtubule organizing center; cytosol

Molecular Function: nucleoside kinase activity; nucleoside diphosphate kinase activity; adenylate kinase activity; ATP binding

Biological Process: ATP metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; pyrimidine ribonucleotide biosynthetic process; ADP biosynthetic process; nucleoside diphosphate phosphorylation; dADP biosynthetic process
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Research Articles on AK5

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AK5 antibody

 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 Adenosine Ribonucleotides De Novo Biosynthesis Pathway antibodies  Adenosine Ribonucleotides De Novo Biosynthesis Pathway Diagram
 Purine Deoxyribonucleosides Salvage Pathway antibodies  Purine Deoxyribonucleosides Salvage Pathway Diagram
 Superpathway Of Purine Nucleotides De Novo Biosynthesis I antibodies  Superpathway Of Purine Nucleotides De Novo Biosynthesis I Diagram

Diseases associated with anti-AK5 antibody

 Disease Name  Pubmed Publications
 Respiratory Tract Diseases Antibodies  >1 publications with AK5 and Respiratory Tract Diseases
 Disease Models, Animal Antibodies  >1 publications with AK5 and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with AK5 and Breast Neoplasms
 Nervous System Diseases Antibodies  >1 publications with AK5 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with AK5 and Cardiovascular Diseases
 Brain Diseases Antibodies  >1 publications with AK5 and Brain Diseases
 Immune System Diseases Antibodies  >1 publications with AK5 and Immune System Diseases
 Liver Neoplasms, Experimental Antibodies  >1 publications with AK5 and Liver Neoplasms, Experimental
 Neoplasms, Experimental Antibodies  >1 publications with AK5 and Neoplasms, Experimental

Organs/Tissues associated with anti-AK5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with AK5 and Brain
 Mixed Antibodies  >1 publications with AK5 and Mixed
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