APLP-1 Antibody – Rabbit Polyclonal

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

APLP1: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. Belongs to the APP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to membrane; plasma membrane; basement membrane

Molecular Function: heparin binding; identical protein binding; protein binding; alpha-2C adrenergic receptor binding; transition metal ion binding; alpha-2B adrenergic receptor binding; alpha-2A adrenergic receptor binding

Biological Process: regulation of translation; nervous system development; negative regulation of cAMP biosynthetic process; organ morphogenesis; extracellular matrix organization and biogenesis; apoptosis; forebrain development; mRNA polyadenylation; endocytosis; G-protein signaling, adenylate cyclase inhibiting pathway; cell adhesion