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CAPN1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2564666

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CAPN1, Polyclonal Antibody
Full Product Name
CAPN1 Polyclonal Antibody
Product Gene Name
anti-CAPN1 antibody
Product Synonym Names
CAPN1; CANP; CANP1; CANPL1; SPG76; muCANP; muCL; calpain 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
81,890 Da
OMIM
114220
3D Structure
ModBase 3D Structure for P07384
Immunogen
Recombinant fusion protein of human CAPN1 (NP_0051772)
Conjugation
Unconjugated

Product Categories/Family for anti-CAPN1 antibody

Cancer; Cell Biology; Signal Transduction; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CAPN1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-CAPN1 antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-CAPN1 antibody

Immunohistochemistry of paraffin-embedded Mouse heart using CAPN1 Polyclonal Antibody at dilution of 1:100 (40x lens).
Rabbit Anti-CAPN1 Polyclonal Antibody – Cat# MBS2564666

Other Notes

Small volumes of anti-CAPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAPN1 purchase

MBS2564666 is an antibody targeting CAPN1. Also known as CAPN1 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CAPN1. It may not necessarily be applicable to this product.

NCBI GI #
119594774
NCBI GeneID
823
NCBI Accession #
EAW74368.1
UniProt Primary Accession #
P07384
UniProt Secondary Accession #
Q2TTR0; Q6DHV4
UniProt Related Accession #
P07384
NCBI Official Full Name
calpain 1, (mu/I) large subunit, isoform CRA_c
NCBI Official Synonym Full Names
calpain 1, (mu/I) large subunit
NCBI Official Symbol
CAPN1
NCBI Official Synonym Symbols
CANP; muCL; CANP1; CANPL1; muCANP
UniProt Protein Name
Calpain-1 catalytic subunit
UniProt Synonym Protein Names
Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain
Protein Family
Calpain
UniProt Gene Name
CAPN1
UniProt Synonym Gene Names
CANPL1; CANP 1; muCANP
UniProt Entry Name
CAN1_HUMAN
NCBI Protein Information
calpain-1 catalytic subunit; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein

UniProt Comments for CAPN1

CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family.

Protein type: EC 3.4.22.52; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: focal adhesion; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; receptor catabolic process; positive regulation of cell proliferation; proteolysis
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Research Articles on CAPN1

1. The PC1 function on JAK2 and ERK signaling pathways might be regulated by calpains in response to the changes in intracellular calcium concentration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CAPN1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >18 publications with CAPN1 and Nervous System Diseases
 Neoplasms Antibodies  >10 publications with CAPN1 and Neoplasms
 Inflammation Antibodies  >5 publications with CAPN1 and Inflammation
 Necrosis Antibodies  >5 publications with CAPN1 and Necrosis
 Nerve Degeneration Antibodies  >4 publications with CAPN1 and Nerve Degeneration
 Heart Diseases Antibodies  >4 publications with CAPN1 and Heart Diseases
 Fibrosis Antibodies  >4 publications with CAPN1 and Fibrosis
 Weight Gain Antibodies  >3 publications with CAPN1 and Weight Gain
 Edema Antibodies  >2 publications with CAPN1 and Edema
 Breast Neoplasms Antibodies  >2 publications with CAPN1 and Breast Neoplasms

Organs/Tissues associated with anti-CAPN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with CAPN1 and Brain
 Connective Tissue Antibodies  >6 publications with CAPN1 and Connective Tissue
 Testis Antibodies  >4 publications with CAPN1 and Testis
 Lymph Node Antibodies  >1 publications with CAPN1 and Lymph Node
 Spleen Antibodies  >1 publications with CAPN1 and Spleen
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