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CCL4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6282069

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CCL4, Polyclonal Antibody
Full Product Name
CCL4, ID (CCL4, LAG1, MIP1B, SCYA4, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, HC21, Lymphocyte activation gene 1 protein, MIP-1-beta(1-69), Macrophage inflammatory protein 1-beta, PAT 744, Protein H400, SIS-gamma, Small-inducible cytokine
Product Gene Name
anti-CCL4 antibody
Product Synonym Names
CCL4; LAG1; MIP1B; SCYA4; C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; MIP-1-beta(3-69)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
9,505 Da
OMIM
182284
3D Structure
ModBase 3D Structure for P13236
Immunogen
CCL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-56 amino acids from the Central region of human CCL4.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-CCL4 antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-CCL4 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CCL4 antibody
IHC: 1:50-100
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CCL4 antibody

CCL4 Antibody (Center) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the CCL4 antibody detected CCL4 protein (arrow).
Rabbit Anti-CCL4 Polyclonal Antibody – Cat# MBS6282069

Immunohistochemistry (IHC) of anti-CCL4 antibody

CCL4 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CCL4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CCL4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6282069

Product References and Citations for anti-CCL4 antibody

Colobran, R., et al. Clin. Exp. Immunol. 162(1):41-52(2010). Lajoie, J., et al. J. Clin. Immunol. 30(1):90-98(2010). Colobran, R., et al. Genes Immun. 10(3):254-259(2009). Shostakovich-Koretskaya, L., et al. AIDS 23(6):679-688(2009). Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008).

Other Notes

Small volumes of anti-CCL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL4 purchase

MBS6282069 is an antibody targeting CCL4. Also known as CCL4, ID (CCL4, LAG1, MIP1B, SCYA4, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, HC21, Lymphocyte activation gene 1 protein, MIP-1-beta(1-69), Macrophage inflammatory protein 1-beta, PAT 744, Protein H400, SIS-gamma, Small-inducible cytokine. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL4. It may not necessarily be applicable to this product.

NCBI GI #
46275832
NCBI GeneID
388372
NCBI Accession #
NP_996890.1
NCBI Related Accession #
NP_002975.1; NP_001001435.1
UniProt Primary Accession #
P13236
UniProt Secondary Accession #
Q50EM1; Q50EM2; Q50EM3; Q50EM4; Q50EM5; Q50EM6; Q50EM7; Q50EM8; Q569J2; B2RUZ3; B7ZMA8
UniProt Related Accession #
Q8NHW4
GenBank Nucleotide #
NM_207007.3
NCBI Official Full Name
C-C motif chemokine 4-like
NCBI Official Synonym Full Names
C-C motif chemokine ligand 4 like 1
NCBI Official Symbol
CCL4L1
NCBI Official Synonym Symbols
LAG1; CCL4L; LAG-1; SCYA4L; AT744.2; SCYA4L1; SCYA4L2; MIP-1-beta
UniProt Protein Name
C-C motif chemokine 4
UniProt Synonym Protein Names
G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; ACT-2
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL4
UniProt Synonym Gene Names
LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2
UniProt Entry Name
CCL4_HUMAN
NCBI Protein Information
C-C motif chemokine 4-like

NCBI Summary for CCL4

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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UniProt Comments for CCL4

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: cell-cell signaling; response to toxin; response to virus; establishment and/or maintenance of cell polarity; positive regulation of calcium-mediated signaling; immune response; positive regulation of calcium ion transport; inflammatory response; cell motility; signal transduction; cell adhesion
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Research Articles on CCL4

1. identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CCL4 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with anti-CCL4 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4 publications with CCL4 and Immune System Diseases
 Disease Progression Antibodies  >3 publications with CCL4 and Disease Progression
 Disease Susceptibility Antibodies  >3 publications with CCL4 and Disease Susceptibility
 Diabetes Mellitus Antibodies  >1 publications with CCL4 and Diabetes Mellitus

Organs/Tissues associated with anti-CCL4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with CCL4 and Blood
 Kidney Antibodies  >2 publications with CCL4 and Kidney
 Liver Antibodies  >1 publications with CCL4 and Liver
 Lung Antibodies  >1 publications with CCL4 and Lung
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