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DCPS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6375733

Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA… More details

$1165 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DCPS, Polyclonal Antibody
Full Product Name
DCPS (DCS1, HINT5, m7GpppX Diphosphatase, DCS-1, Hint-related 7meGMP-directed Hydrolase, Histidine Triad Protein Member 5, Scavenger mRNA-decapping Enzyme DcpS, HSPC015) APC
Product Gene Name
anti-DCPS antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human DCPS. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
38,609 Da
OMIM
610534
3D Structure
ModBase 3D Structure for Q96C86
Immunogen
Full length human DCPS, aa1-337 (NP_054745.1).
Immunogen Sequence
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
Conjugate
APC
Note
Preservative Free

Product Categories/Family for anti-DCPS antibody

Antibodies; Enzymes; Phosphatase
Applications Tested/Suitable for anti-DCPS antibody
Western Blot (WB)
Application Notes for anti-DCPS antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DCPS antibody

DCPS rabbit polyclonal antibody. Western Blot analysis of DCPS expression in mouse liver.
Rabbit Anti-DCPS Polyclonal Antibody – Cat# MBS6375733

Western Blot (WB) of anti-DCPS antibody

Western Blot analysis of DCPS expression in transfected 293T cell line by DCPS polyclonal antibody. Lane 1: DCPS transfected lysate (38.6kD). Lane 2: Non-transfected lysate.
Rabbit Anti-DCPS Polyclonal Antibody, Western Blot (WB) – Cat# MBS6375733

Other Notes

Small volumes of anti-DCPS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCPS purchase

MBS6375733 is an antibody targeting DCPS. Also known as DCPS (DCS1, HINT5, m7GpppX Diphosphatase, DCS-1, Hint-related 7meGMP-directed Hydrolase, Histidine Triad Protein Member 5, Scavenger mRNA-decapping Enzyme DcpS, HSPC015) APC. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DCPS. It may not necessarily be applicable to this product.

NCBI GI #
7661734
NCBI GeneID
28960
NCBI Accession #
NP_054745.1
UniProt Primary Accession #
Q96C86
UniProt Secondary Accession #
Q8NHL8; Q9Y2S5
UniProt Related Accession #
Q96C86
GenBank Nucleotide #
NM_014026
NCBI Official Full Name
m7GpppX diphosphatase
NCBI Official Synonym Full Names
decapping enzyme, scavenger
NCBI Official Symbol
DCPS
NCBI Official Synonym Symbols
DCS1; HSL1; HINT5; HINT-5; HSPC015
UniProt Protein Name
m7GpppX diphosphatase
UniProt Synonym Protein Names
DCS-1; Decapping scavenger enzyme; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; HINT-5; Scavenger mRNA-decapping enzyme DcpS
Protein Family
m7GpppX diphosphatase
UniProt Gene Name
DCPS
UniProt Synonym Gene Names
DCS1; HINT5; HINT-5
UniProt Entry Name
DCPS_HUMAN
NCBI Protein Information
m7GpppX diphosphatase; decapping scavenger enzyme; heat shock-like protein 1; hint-related 7meGMP-directed hydrolase; histidine triad nucleotide-binding protein 5; histidine triad protein member 5; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; mR

UniProt Comments for DCPS

DCPS: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides. Belongs to the HIT family.

Protein type: EC 3.6.1.59; Hydrolase; RNA splicing

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; m7G(5')pppN diphosphatase activity; RNA 7-methylguanosine cap binding

Biological Process: deadenylation-dependent decapping; negative regulation of programmed cell death; gene expression; nuclear mRNA cis splicing, via U2-type spliceosome; mRNA catabolic process, deadenylation-dependent decay

Disease: Al-raqad Syndrome
Show more

Research Articles on DCPS

1. Data established that DcpS, a key enzyme in mRNA decay, is a new target of DeltaLf transcriptional activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DCPS antibody

 Products by Pathway  Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 MRNA Decay By 3' To 5' Exoribonuclease Pathway antibodies  MRNA Decay By 3' To 5' Exoribonuclease Pathway Diagram

Diseases associated with anti-DCPS antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with DCPS and Nervous System Diseases
 Pain Antibodies  >7 publications with DCPS and Pain
 Cardiovascular Diseases Antibodies  >4 publications with DCPS and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >3 publications with DCPS and Neoplasms, Experimental
 Necrosis Antibodies  >3 publications with DCPS and Necrosis
 Disease Models, Animal Antibodies  >3 publications with DCPS and Disease Models, Animal
 Inflammation Antibodies  >3 publications with DCPS and Inflammation
 Liver Diseases Antibodies  >2 publications with DCPS and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with DCPS and Carcinoma, Hepatocellular
 Carcinoma Antibodies  >2 publications with DCPS and Carcinoma

Organs/Tissues associated with anti-DCPS antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >23 publications with DCPS and Bone
 Blood Antibodies  >21 publications with DCPS and Blood
 Brain Antibodies  >10 publications with DCPS and Brain
 Skin Antibodies  >6 publications with DCPS and Skin
 Liver Antibodies  >5 publications with DCPS and Liver
 Heart Antibodies  >4 publications with DCPS and Heart
 Vascular Antibodies  >3 publications with DCPS and Vascular
 Muscle Antibodies  >3 publications with DCPS and Muscle
 Connective Tissue Antibodies  >2 publications with DCPS and Connective Tissue
 Lung Antibodies  >2 publications with DCPS and Lung
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