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FAM134B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9611748

Description: Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the… More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FAM134B, Polyclonal Antibody
Full Product Name
FAM134B Antibody
Product Gene Name
anti-FAM134B antibody
Product Synonym Gene Name
RETREG1
Product Synonym Names
F134B_HUMAN; FAM134B; family with sequence similarity 134 member B; HSAN2B; JK 1; JK1; Protein FAM134B
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
peptide affinity purification
Concentration
1mg/ml (lot specific)
Specificity
FAM134B Antibody detects endogenous levels of FAM134B.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
FAM134B peptide (MBS9621701) is used for blocking the activity of FAM134B antibody (MBS9611748)
Molecular Weight
65 kDa
OMIM
gene 613115
3D Structure
ModBase 3D Structure for Q9H6L5
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human FAM134B, corresponding to a region within the internal amino acids.
Important
For western blot, incubate membrane with diluted primary Ab in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FAM134B antibody
Western Blot (WB)
Application Notes for anti-FAM134B antibody
WB: 1:500-1:2000
IF/ICC: 1:100-1:500
*The optimal dilutions should be determined by the end user.

Western Blot (WB) of anti-FAM134B antibody

Western blot analysis of extracts from HepG2, using FAM134B Antibody. The lane on the left was treated with blocking peptide.
Rabbit Anti-FAM134B Polyclonal Antibody – Cat# MBS9611748

Immunofluorescence (IF) of anti-FAM134B antibody

MBS9611748 staining Hela cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. Samples were then incubated with primary Ab(MBS9611748 1:200) and mouse antibeta tubulin Ab(MBS9610328 1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) Ab(Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) Ab(Green) were used as the secondary antibody.
Rabbit Anti-FAM134B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9611748

Other Notes

Small volumes of anti-FAM134B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAM134B purchase

MBS9611748 is an antibody targeting FAM134B. Also known as FAM134B Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FAM134B. It may not necessarily be applicable to this product.

NCBI GI #
77917617
NCBI GeneID
54463
NCBI Accession #
NP_001030022.1
UniProt Primary Accession #
Q9H6L5
UniProt Related Accession #
Q9H6L5
GenBank Nucleotide #
NP_001030022.1
NCBI Official Full Name
reticulophagy regulator 1 isoform 1
NCBI Official Synonym Full Names
reticulophagy regulator 1
NCBI Official Symbol
RETREG1
NCBI Official Synonym Symbols
JK1; JK-1; FAM134B
UniProt Protein Name
Protein FAM134B
Protein Family
Reticulophagy receptor
UniProt Gene Name
FAM134B
UniProt Entry Name
F134B_HUMAN
NCBI Protein Information
reticulophagy regulator 1

NCBI Summary for FAM134B

The protein encoded by this gene is a cis-Golgi transmembrane protein that may be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Mutations in this gene are a cause of hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), and this gene may also play a role in susceptibility to vascular dementia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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Research Articles on FAM134B

1. Through molecular dynamic simulations of FAM134B in flat and curved membranes, we relate the dynamic RHD structure with its two wedge-shaped transmembrane helical hairpins and two amphipathic helices to FAM134B functions in membrane-curvature induction and curvature-mediated protein sorting.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FAM134B antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with FAM134B and Nervous System Diseases
 Hereditary Sensory and Autonomic Neuropathies Antibodies  >4 publications with FAM134B and Hereditary Sensory and Autonomic Neuropathies
 Nervous System Malformations Antibodies  >3 publications with FAM134B and Nervous System Malformations
 Nerve Degeneration Antibodies  >1 publications with FAM134B and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >1 publications with FAM134B and Cardiovascular Diseases
 Brain Diseases Antibodies  >1 publications with FAM134B and Brain Diseases
 Mental Disorders Antibodies  >1 publications with FAM134B and Mental Disorders
 Arteriosclerosis Antibodies  >1 publications with FAM134B and Arteriosclerosis
 Pain Antibodies  >1 publications with FAM134B and Pain
 Neoplasms Antibodies  >1 publications with FAM134B and Neoplasms

Organs/Tissues associated with anti-FAM134B antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with FAM134B and Skin
 Nerve Antibodies  >1 publications with FAM134B and Nerve
 Brain Antibodies  >1 publications with FAM134B and Brain
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