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H2AFY2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9200885

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
H2AFY2, Polyclonal Antibody
Full Product Name
H2AFY2 Antibody (N-term)
Product Gene Name
anti-H2AFY2 antibody
Product Synonym Names
Core histone macro-H2A2; Histone macroH2A2; mH2A2; H2AFY2; MACROH2A2
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This H2AFY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human H2AFY2.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
H2AFY2 peptide (MBS9217823) is used for blocking the activity of H2AFY2 antibody (MBS9200885)
Molecular Weight
40058
Immunogen Sequence Positions
11-39
OMIM
616141
3D Structure
ModBase 3D Structure for Q9P0M6
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Applications Tested/Suitable for anti-H2AFY2 antibody
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)
Application Notes for anti-H2AFY2 antibody
WB~~1:1000

Western Blot (WB) of anti-H2AFY2 antibody

H2AFY2 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the H2AFY2 antibody detected the H2AFY2 protein (arrow).
Rabbit Anti-H2AFY2 Polyclonal Antibody – Cat# MBS9200885

Flow Cytometry (FC/FACS) of anti-H2AFY2 antibody

H2AFY2 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-H2AFY2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9200885

Product References and Citations for anti-H2AFY2 antibody

Xu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2136-2140(2010)
Sporn, J.C., et al. Oncogene 28(38):3423-3428(2009)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Zhang, R., et al. Dev. Cell 8(1):19-30(2005)
Deloukas, P., et al. Nature 429(6990):375-381(2004)

Other Notes

Small volumes of anti-H2AFY2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for H2AFY2 purchase

MBS9200885 is an antibody targeting H2AFY2. Also known as H2AFY2 Antibody (N-term). Reactive in Human, mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for H2AFY2. It may not necessarily be applicable to this product.

NCBI GI #
8923920
NCBI GeneID
55506
NCBI Accession #
NP_061119.1
UniProt Primary Accession #
Q9P0M6
UniProt Secondary Accession #
Q5SQT2
UniProt Related Accession #
Q9P0M6
GenBank Nucleotide #
NM_018649.2
NCBI Official Full Name
core histone macro-H2A.2
NCBI Official Synonym Full Names
H2A histone family, member Y2
NCBI Official Symbol
H2AFY2
NCBI Official Synonym Symbols
macroH2A2
UniProt Protein Name
Core histone macro-H2A.2
Protein Family
Core histone macro
UniProt Gene Name
H2AFY2
UniProt Synonym Gene Names
MACROH2A2; Histone macroH2A2; mH2A2
UniProt Entry Name
H2AW_HUMAN
NCBI Protein Information
core histone macro-H2A.2

NCBI Summary for H2AFY2

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Aug 2015]
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UniProt Comments for H2AFY2

H2AFY2: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: nucleoplasm; ESC/E(Z) complex; nuclear chromatin; Barr body; nucleosome; nucleus

Molecular Function: protein heterodimerization activity; chromatin DNA binding

Biological Process: nucleosome assembly; negative regulation of gene expression, epigenetic; dosage compensation; chromatin modification; regulation of cell growth; brain development; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on H2AFY2

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-H2AFY2 antibody

 Products by Pathway  Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram

Diseases associated with anti-H2AFY2 antibody

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >2 publications with H2AFY2 and Neurodegenerative Diseases
 Brain Diseases Antibodies  >2 publications with H2AFY2 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with H2AFY2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >1 publications with H2AFY2 and Disease Models, Animal
 Nerve Degeneration Antibodies  >1 publications with H2AFY2 and Nerve Degeneration

Organs/Tissues associated with anti-H2AFY2 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with H2AFY2 and Nerve
 Adrenal Gland Antibodies  >1 publications with H2AFY2 and Adrenal Gland
 Liver Antibodies  >1 publications with H2AFY2 and Liver
 Kidney Antibodies  >1 publications with H2AFY2 and Kidney
 Brain Antibodies  >1 publications with H2AFY2 and Brain
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