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MCM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3907381

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6,… More details

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Product Overview

Online Datasheet in PDF
Product Name
MCM2, Polyclonal Antibody
Full Product Name
Rabbit anti-Phospho MCM2 (S108) IHC Antibody, Affinity Purified
Product Gene Name
anti-MCM2 antibody
Product Synonym Names
MCM2, Phospho (S108); D3S3194; MITOTIN; minichromosome maintenance protein 2 homolog; minichromosome maintenance deficient 2 (mitotin); nuclear protein BM28; DFNA70; cell devision cycle-like 1; CDCL1; cdc19; CCNL1; BM28; DNA replication licensing factor MCM2; cyclin-like 1; DNA replication licensing factor MCM2; minichromosome maintenance complex component 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
100ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
OMIM
116945
3D Structure
ModBase 3D Structure for P49736
Predicted Reactivity
Rat, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Crab-eating macaque, African elephant, White-tufted-ear marmoset, Tasmanian devil, Zebra finch, Gray short-tailed opossum, Green anole, Chinese hamster, Small-eared galago, Naked mole rat, Duckbill platypus, Thirteen-lined ground squirrel, Little brown bat
Immunogen
Surrounding serine 108
Conjugation
Unconjugated

Product Categories/Family for anti-MCM2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-MCM2 antibody
Immunohistochemistry (IHC), Immunohistochemistry-Immunofluorescence (IHC-IF)
Application Notes for anti-MCM2 antibody
IHC: 1:100-1:500
IHC-IF: 1:50-1:500

Immunohistochemistry (IHC) of anti-MCM2 antibody

Detection of mouse phospho-MCM2 (Ser 108) by immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-Phospho-MCM2 (Ser 108) (Cat. No. MBS3907381) used at a dilution of 1:100. Detection: DAB
Rabbit Anti-MCM2 Polyclonal Antibody – Cat# MBS3907381

Immunohistochemistry (IHC) of anti-MCM2 antibody

Detection of human phospho-MCM2 (Ser 108) by immunohistochemistry. Sample: FFPE section of human seminoma. Antibody: Affinity purified rabbit anti-Phospho-MCM2 (Ser 108) (Cat. No. MBS3907381) used at a dilution of 1:100. Detection: DAB
Rabbit Anti-MCM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907381

Immunohistochemistry (IHC) of anti-MCM2 antibody

Detection of human Phospho MCM2 (Ser 108) by immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Phospho-MCM2 (Ser 108) (Cat. No. MBS3907381) used at a dilution of 1:100. Detection: Red-fluorescent Alexa Fluor 555 goat antirabbit IgG (Invitrogen) used at a dilution of 1:500.
Rabbit Anti-MCM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907381

Immunohistochemistry (IHC) of anti-MCM2 antibody

Detection of human Phospho MCM2 (Ser 108) by immunohistochemistry. Sample: FFPE section of human small cell lung cancer. Antibody: Affinity purified rabbit anti-Phospho-MCM2 (Ser 108) (Cat. No. MBS3907381) used at a dilution of 1:100. Detection: Red-fluorescent Alexa Fluor 555 goat antirabbit IgG (Invitrogen) used at a dilution of 1:500.
Rabbit Anti-MCM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907381

Other Notes

Small volumes of anti-MCM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCM2 purchase

MBS3907381 is an antibody targeting MCM2. Also known as Rabbit anti-Phospho MCM2 (S108) IHC Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCM2. It may not necessarily be applicable to this product.

NCBI GeneID
0
NCBI Accession #
NP_0045117.2
UniProt Primary Accession #
P49736
UniProt Protein Name
DNA replication licensing factor MCM2
UniProt Synonym Protein Names
Minichromosome maintenance protein 2 homolog; Nuclear protein BM28
Protein Family
DNA replication licensing factor
UniProt Gene Name
MCM2
UniProt Synonym Gene Names
BM28; CCNL1; CDCL1; KIAA0030
UniProt Entry Name
MCM2_HUMAN

UniProt Comments for MCM2

MCM2: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: DNA-binding; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: microtubule cytoskeleton; nucleoplasm; MCM complex; cytoplasm; chromatin; nuclear origin of replication recognition complex; nucleus

Molecular Function: protein binding; DNA helicase activity; DNA binding; histone binding; metal ion binding; DNA replication origin binding; ATP binding

Biological Process: DNA unwinding during replication; nucleosome assembly; DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; cell cycle; DNA replication; G1/S transition of mitotic cell cycle
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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