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MSC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9207579

The protein encoded by this gene is a transcriptionalrepressor capable of binding an E-box element either as a homodimeror as a heterodimer with E2A in vitro. The encoded protein alsoforms heterodimers with E2A proteins in vivo. This protein iscapable of… More details

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Product Overview

Online Datasheet in PDF
Product Name
MSC, Polyclonal Antibody
Full Product Name
MSC Antibody (C-term)
Product Gene Name
Product Synonym Names
Musculin; Activated B-cell factor 1; ABF-1; Class A basic helix-loop-helix protein 22; bHLHa22; MSC; ABF1; BHLHA22
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This MSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the C-terminal region of human MSC.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
MSC peptide (MBS9222955) is used for blocking the activity of MSC antibody (MBS9207579)
Molecular Weight
22068
Immunogen Sequence Positions
166-194
OMIM
603628
3D Structure
ModBase 3D Structure for O60682
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Applications Tested/Suitable for anti-MSC antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-MSC antibody
WB~~1:1000

Western Blot (WB) of anti-MSC antibody

MSC Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MSC antibody detected the MSC protein (arrow).
Rabbit Anti-MSC Polyclonal Antibody – Cat# MBS9207579

Product References and Citations for anti-MSC antibody

Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ushmorov, A., et al. Leukemia 22(10):1942-1944(2008)
Knight, J.C., et al. Nat. Genet. 36(4):394-399(2004)
Wong, J., et al. DNA Cell Biol. 20(8):465-471(2001)
Robb, L., et al. Genomics 57(2):318-319(1999)

Other Notes

Small volumes of anti-MSC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MSC purchase

MBS9207579 is an antibody targeting MSC. Also known as MSC Antibody (C-term). Reactive in Human, mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MSC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
musculin
NCBI Official Synonym Full Names
musculin
NCBI Official Symbol
MSC
NCBI Official Synonym Symbols
ABF1; MYOR; ABF-1; bHLHa22
UniProt Protein Name
Musculin
UniProt Synonym Protein Names
Activated B-cell factor 1; ABF-1; Class A basic helix-loop-helix protein 22; bHLHa22
Protein Family
UniProt Gene Name
MSC
UniProt Synonym Gene Names
ABF1; BHLHA22; ABF-1; bHLHa22
UniProt Entry Name
MUSC_HUMAN
NCBI Protein Information
musculin

NCBI Summary for MSC

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]
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UniProt Comments for MSC

MSC: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: nucleus

Molecular Function: protein dimerization activity; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; branchiomeric skeletal muscle development; palate development; negative regulation of transcription from RNA polymerase II promoter
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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