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NEU4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6324778

The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NEU4, Polyclonal Antibody
Full Product Name
NEU4, CT (NEU4, Sialidase-4, N-acetyl-alpha-neuraminidase 4) (MaxLight 405)
Product Gene Name
anti-NEU4 antibody
Product Synonym Names
NEU4; Sialidase-4; N-acetyl-alpha-neuraminidase 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human NEU4. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
53,066 Da
OMIM
608527
3D Structure
ModBase 3D Structure for Q8WWR8
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 423-452 in the C-terminal region of human NEU4, UniProt Accession #Q8WWR8.
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-NEU4 antibody

Antibodies; Enzymes; Glycosidase
Applications Tested/Suitable for anti-NEU4 antibody
Western Blot (WB), Immunohistochemistry (IHC), FLISA
Application Notes for anti-NEU4 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-NEU4 antibody

Western Blot analysis in mouse liver tissue lysates (35ug/lane) usingMBS6009069. This demonstrates that MBS6009069 detected the NEU4 protein (arrow).
Rabbit Anti-NEU4 Polyclonal Antibody – Cat# MBS6324778

Immunohistochemistry (IHC) of anti-NEU4 antibody

Immunohistochemistry analysis of formalin fixed and paraffin embedded human hepatocarcinoma using MBS6009069 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6009069 for immunohistochemistry.
Rabbit Anti-NEU4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6324778

Product References and Citations for anti-NEU4 antibody

1. Bigi, A., et al. Glycobiology 20(2):148-157(2010). 2. Xin, X., et al. Genome Res. 19(7):1262-1269(2009). 3. Miyagi, T., et al. Proteomics 8(16):3303-3311(2008). 4. Stamatos, N.M., et al. FEBS J. 272(10):2545-2556(2005). 5. Hillier, L.W., et al. Nature 434(7034):724-731 (2005).

Other Notes

Small volumes of anti-NEU4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NEU4 purchase

MBS6324778 is an antibody targeting NEU4. Also known as NEU4, CT (NEU4, Sialidase-4, N-acetyl-alpha-neuraminidase 4) (MaxLight 405). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NEU4. It may not necessarily be applicable to this product.

NCBI GI #
262527265
NCBI GeneID
129807
NCBI Accession #
NP_001161072.1
NCBI Related Accession #
NP_542779.2; NP_001161074.1; NP_001161071.1; NP_001161073.1
UniProt Primary Accession #
Q8WWR8
UniProt Secondary Accession #
Q96D64; A8K056; J3KNJ5
UniProt Related Accession #
Q8WWR8
GenBank Nucleotide #
NM_001167600.2
NCBI Official Full Name
sialidase-4 isoform 3
NCBI Official Synonym Full Names
neuraminidase 4
NCBI Official Symbol
NEU4
UniProt Protein Name
Sialidase-4
UniProt Synonym Protein Names
N-acetyl-alpha-neuraminidase 4
Protein Family
Sialidase
UniProt Gene Name
NEU4
UniProt Entry Name
NEUR4_HUMAN
NCBI Protein Information
sialidase-4

UniProt Comments for NEU4

NEU4: May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. Belongs to the glycosyl hydrolase 33 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - sphingolipid; EC 3.2.1.18; Hydrolase; Glycan Metabolism - other glycan degradation

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: lysosomal lumen; organelle inner membrane; mitochondrion; lysosome

Molecular Function: protein binding; exo-alpha-sialidase activity

Biological Process: oligosaccharide catabolic process; cellular protein metabolic process; sphingolipid metabolic process; dolichol-linked oligosaccharide biosynthetic process; ganglioside catabolic process; glycosphingolipid metabolic process; protein amino acid N-linked glycosylation via asparagine; glycoprotein catabolic process; post-translational protein modification
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Research Articles on NEU4

1. The silencing or chemical inhibition of NEU4 changes the entire glycosylation pattern of proteins and lipids, making it more similar to that of differentiated GBM cells and drastically reduces GSCs survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NEU4 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Other Glycan Degradation Pathway antibodies  Other Glycan Degradation Pathway Diagram
 Other Glycan Degradation Pathway antibodies  Other Glycan Degradation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Sialic Acid Metabolism Pathway antibodies  Sialic Acid Metabolism Pathway Diagram

Diseases associated with anti-NEU4 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with NEU4 and Liver Diseases
 Inflammation Antibodies  >2 publications with NEU4 and Inflammation
 Ovarian Neoplasms Antibodies  >1 publications with NEU4 and Ovarian Neoplasms
 Lung Diseases Antibodies  >1 publications with NEU4 and Lung Diseases
 Immune System Diseases Antibodies  >1 publications with NEU4 and Immune System Diseases

Organs/Tissues associated with anti-NEU4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with NEU4 and Brain
 Blood Antibodies  >10 publications with NEU4 and Blood
 Liver Antibodies  >7 publications with NEU4 and Liver
 Kidney Antibodies  >4 publications with NEU4 and Kidney
 Lung Antibodies  >2 publications with NEU4 and Lung
 Eye Antibodies  >1 publications with NEU4 and Eye
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