Rabbit Anti-PAPD7 Polyclonal Antibody – Cat# MBS9631064

PAPD7 Antibody – Rabbit Polyclonal

Name: PAPD7 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9631064
Price: 325 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9631064

MBS9631064 is an antibody targeting PAPD7. Also known as PAPD7 Antibody. Reactive in Human, Mouse. Host: Rabbit. More details

$325 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAPD7, Polyclonal Antibody

Full Product Name

PAPD7 Antibody

Product Gene Name

anti-PAPD7 antibody

Product Synonym Names

DNA polymerase kappa; DNA polymerase sigma; LAK 1; LAK-1; LAK1; OTTHUMP00000115520; PAP associated domain containing 7; PAP-associated domain-containing protein 7; Papd7; PAPD7_HUMAN; POLK; POLS; Polymerase (DNA directed) sigma; Polymerase DNA Directed Sigma; Terminal uridylyltransferase 5; Topoisomerase related function protein 4 1; Topoisomerase-related function protein 4-1; TRF4 1; TRF4; TRF4-1; TRF41; TUTase 5; TUTASE5

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).

Concentration

1mg/ml (lot specific)

Specificity

PAPD7 Antibody detects endogenous levels of PAPD7.

Preparation and Storage

Store at -20 degree C. Stable for 12 months from date of receipt.

Antibody/Peptide Pairs

PAPD7 peptide (MBS9633447) is used for blocking the activity of PAPD7 antibody (MBS9631064)

Molecular Weight

59,874 Da

OMIM

605198

3D Structure

ModBase 3D Structure for Q5XG87

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Immunogen

A synthesized peptide derived from human PAPD7.

Conjugation

Unconjugated

Similarity

Belongs to the DNA polymerase type-B-like family.

Subunit Structure

Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.

Function

Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.

Note

Excluded from nucleolus, weak staining detected in the cytoplasm.

Product Categories/Family for anti-PAPD7 antibody

Cytoplasm; Nucleus; Nucleoplasm; Primary

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-PAPD7 antibody

ELISA (EIA)(peptide)

Application Notes for anti-PAPD7 antibody

ELISA(peptide): 1:20000-1:40000

Other Notes

Small volumes of anti-PAPD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAPD7. It may not necessarily be applicable to this product.

NCBI GI #

284507291

NCBI GeneID

11044

NCBI Accession #

NP_008930.1

UniProt Primary Accession #

Q5XG87

UniProt Secondary Accession #

O43289; Q17RZ1; Q9Y6C1; A8K1E2; M1JCE6

UniProt Related Accession #

Q5XG87

GenBank Nucleotide #

NM_006999

NCBI Official Full Name

Homo sapiens PAP associated domain containing 7 (PAPD7), transcript variant 1, mRNA

NCBI Official Synonym Full Names

PAP associated domain containing 7

NCBI Official Symbol

PAPD7

NCBI Official Synonym Symbols

LAK1; POLK; POLS; TRF4; LAK-1; TRF41; TRF4-1; TUTASE5

UniProt Protein Name

Non-canonical poly(A) RNA polymerase PAPD7

UniProt Synonym Protein Names

DNA polymerase sigma; LAK-1; PAP-associated domain-containing protein 7; TRAMP-like complex polyadenylate polymerase; Terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1; TRF4-1

UniProt Gene Name

PAPD7

UniProt Synonym Gene Names

POLS; TRF4; TUTase 5; TRF4-1

UniProt Entry Name

PAPD7_HUMAN

NCBI Protein Information

non-canonical poly(A) RNA polymerase PAPD7; non-canonical poly(A) RNA polymerase PAPD7; DNA polymerase kappa; DNA polymerase sigma; PAP-associated domain-containing protein 7; TRAMP-like complex polyadenylate polymerase; TUTase 5; polymerase (DNA directed

NCBI Summary for PAPD7

The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

UniProt Comments for PAPD7

POLS: DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation. Belongs to the DNA polymerase type-B-like family.

Protein type: EC 2.7.7.19; DNA repair, damage; DNA replication; Transferase

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: polynucleotide adenylyltransferase activity; DNA binding; SMC protein binding; metal ion binding; DNA-directed DNA polymerase activity

Biological Process: response to drug; cell division; mitotic chromosome condensation; double-strand break repair; sister chromatid cohesion

Research Articles on PAPD7

1. These results suggest that PAPD7 l is the major and active isoform of PAPD7 expressed in cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PAPD7 antibody

Products by Pathway	Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
TRAMP Complex Pathway antibodies	TRAMP Complex Pathway Diagram
TRAMP Complex Pathway antibodies	TRAMP Complex Pathway Diagram

Diseases associated with anti-PAPD7 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>1 publications with PAPD7 and Brain Diseases
Nervous System Diseases Antibodies	>1 publications with PAPD7 and Nervous System Diseases

Organs/Tissues associated with anti-PAPD7 antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>1 publications with PAPD7 and Eye
Brain Antibodies	>1 publications with PAPD7 and Brain