TEC Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

TEC: a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system.

Protein type: Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; intercellular junction; cytosol

Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; lipid binding; ATP binding; receptor binding

Biological Process: integrin-mediated signaling pathway; adaptive immune response; B cell receptor signaling pathway; tissue regeneration; innate immune response; cell differentiation; T cell receptor signaling pathway; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation