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UBE2A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8548701

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at… More details

$380 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UBE2A, Polyclonal Antibody
Full Product Name
UBE2A Rabbit pAb
Product Gene Name
anti-UBE2A antibody
Product Synonym Names
UBC2; HHR6A; MRXSN; RAD6A; MRXS30
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purity/Purification
Affinity Purified
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
17kDa
OMIM
phenotype 312180
3D Structure
ModBase 3D Structure for P49459
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human UBE2A (NP_003327.2).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-UBE2A antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-UBE2A antibody
WB: 1:500-1:2000
IF: 1:50-1:200

Other Notes

Small volumes of anti-UBE2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBE2A purchase

MBS8548701 is an antibody targeting UBE2A. Also known as UBE2A Rabbit pAb. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UBE2A. It may not necessarily be applicable to this product.

NCBI GI #
33518639
NCBI GeneID
7319
NCBI Accession #
P49459.2
UniProt Primary Accession #
P49459
UniProt Related Accession #
P49459
NCBI Official Full Name
Ubiquitin-conjugating enzyme E2 A
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 A
NCBI Official Symbol
UBE2A
NCBI Official Synonym Symbols
UBC2; HHR6A; MRXSN; RAD6A; MRXS30
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 A
UniProt Synonym Protein Names
RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A
Protein Family
Ubiquitin-conjugating enzyme
UniProt Gene Name
UBE2A
UniProt Synonym Gene Names
RAD6A; HR6A; hHR6A
UniProt Entry Name
UBE2A_HUMAN
NCBI Protein Information
ubiquitin-conjugating enzyme E2 A

NCBI Summary for UBE2A

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for UBE2A

UBE2A: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: XY body; cytoplasm; nuclear chromatin; chromatin; cytosol

Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of peptide antigen via MHC class I; protein autoubiquitination; protein polyubiquitination; maternal process involved in pregnancy; postreplication repair; in utero embryonic development; positive regulation of cell proliferation; DNA repair; histone H2A ubiquitination; response to UV

Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type
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Research Articles on UBE2A

1. UBE2A Q93E mutation, which was identified in two brothers with mild intellectual disability, perturbs the UBE2A catalytic microenvironment essential for lysine deprotonation during ubiquitin transfer, thus generating an enzyme that is disabled but not dead.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBE2A antibody

 Reference Product  PubMed Publications
 UBE2B antibody  >17 publications with UBE2A and UBE2B
 RAD18 antibody  >10 publications with UBE2A and RAD18
 CDK9 antibody  >3 publications with UBE2A and CDK9
 UBE2N antibody  >2 publications with UBE2A and UBE2N
 RNF20 antibody  >2 publications with UBE2A and RNF20
 UBE2V1 antibody  >1 publications with UBE2A and UBE2V1
 RNF40 antibody  >1 publications with UBE2A and RNF40

Pathways associated with anti-UBE2A antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with anti-UBE2A antibody

 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >3 publications with UBE2A and Chromosome Aberrations
 Brain Diseases Antibodies  >2 publications with UBE2A and Brain Diseases
 Skin Diseases Antibodies  >1 publications with UBE2A and Skin Diseases
 Carcinoma Antibodies  >1 publications with UBE2A and Carcinoma
 Inflammation Antibodies  >1 publications with UBE2A and Inflammation

Organs/Tissues associated with anti-UBE2A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with UBE2A and Blood
 Testis Antibodies  >5 publications with UBE2A and Testis
 Brain Antibodies  >5 publications with UBE2A and Brain
 Muscle Antibodies  >2 publications with UBE2A and Muscle
 Heart Antibodies  >2 publications with UBE2A and Heart
 Skin Antibodies  >2 publications with UBE2A and Skin
 Bone Antibodies  >1 publications with UBE2A and Bone
 Bone Marrow Antibodies  >1 publications with UBE2A and Bone Marrow
 Eye Antibodies  >1 publications with UBE2A and Eye
 Intestine Antibodies  >1 publications with UBE2A and Intestine
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